Effects of Alcohol History on Effects of Nitrous Oxide - 9
3 other identifiers
interventional
19
1 country
1
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 1995
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 1995
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 1997
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 1997
CompletedFirst Submitted
Initial submission to the registry
September 20, 1999
CompletedFirst Posted
Study publicly available on registry
September 21, 1999
CompletedMay 28, 2015
May 1, 2015
1.6 years
September 20, 1999
May 26, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Choice of nitrous oxide vs placebo
Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject \& the technician administering the inhalant were blinded. Testing was done at each dose.
After 30 min inhalation each of N2O and placebo
Study Arms (2)
Light drinkers
ACTIVE COMPARATORModerate drinkers
ACTIVE COMPARATORInterventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- University of Chicagolead
- National Institute on Drug Abuse (NIDA)collaborator
Study Sites (1)
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, 60637, United States
Related Publications (1)
Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP. The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Apr 14;45(1-2):63-70. doi: 10.1016/s0376-8716(97)01346-x.
PMID: 9179508BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James Zacny, Ph.D.
University of Chicago
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 20, 1999
First Posted
September 21, 1999
Study Start
September 1, 1995
Primary Completion
April 1, 1997
Study Completion
April 1, 1997
Last Updated
May 28, 2015
Record last verified: 2015-05