Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

40.7%

11 terminated/withdrawn out of 27 trials

Success Rate

56.0%

-30.5% vs industry average

Late-Stage Pipeline

19%

5 trials in Phase 3/4

Results Transparency

71%

10 of 14 completed trials have results

Key Signals

1 recruiting10 with results8 terminated

Enrollment Performance

Analytics

Phase 1
11(42.3%)
Phase 2
10(38.5%)
Phase 3
5(19.2%)
26Total
Phase 1(11)
Phase 2(10)
Phase 3(5)

Activity Timeline

Global Presence

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Clinical Trials (27)

Showing 20 of 27 trials
NCT04331119Phase 2Terminated

Duvelisib Maintenance After Autologous Stem Cell Transplant in T-Cell Lymphomas

Role: collaborator

NCT06522737Phase 3Recruiting

A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype

Role: lead

NCT05044039Phase 1Active Not Recruiting

Duvelisib Following Chimeric Antigen Receptor T-Cell Therapy

Role: collaborator

NCT03372057Phase 2Completed

A Study of Duvelisib in Participants With Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)

Role: lead

NCT04038359Phase 2Completed

A Phase 2 Study Comparing 2 Intermittent Dosing Schedules of Duvelisib in Participants With Indolent Non-Hodgkin Lymphoma

Role: lead

NCT02204982Phase 3Terminated

Study of Duvelisib in Combination With Rituximab vs Rituximab in Subjects With Previously Treated Follicular Lymphoma

Role: lead

NCT02391545Phase 1Terminated

A Study of Duvelisib in Combination With Rituximab or Obinutuzumab in Subjects With Previously Untreated CD20+ Follicular Lymphoma (CONTEMPO)

Role: lead

NCT02004522Phase 3Completed

A Phase 3 Study of Duvelisib Versus Ofatumumab in Patients With Relapsed or Refractory CLL/SLL (DUO)

Role: lead

NCT04193293Phase 1Terminated

A Study of Duvelisib in Combination With Pembrolizumab in Head and Neck Cancer

Role: lead

NCT02049515Phase 3Completed

A Phase 3 Extension Study of Duvelisib and Ofatumumab in Participants With CLL/SLL Previously Enrolled in Study IPI-145-07

Role: lead

NCT02711852Phase 2Completed

A Long-term, Continued Treatment and Follow-up Study in Participants With Hematologic Malignancies Treated With Duvelisib (IPI-145)

Role: lead

NCT01882803Phase 2Completed

A Study of Duvelisib in Participants With Refractory Indolent Non-Hodgkin Lymphoma

Role: lead

NCT03370185Phase 2Withdrawn

Phase 2 Study of Duvelisib in Previously Treated Patients With Chronic Lymphocytic Leukemia /Small Lymphocytic Lymphoma

Role: lead

NCT02292225Phase 1Terminated

Duvelisib With Obinutuzumab in Patients With CLL/SLL Previously Treated With a BTKi (SYNCHRONY)

Role: lead

NCT03256045Phase 2Terminated

Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Role: collaborator

NCT01476657Phase 1Terminated

A Phase 1 Study of Duvelisib in Patients With Advanced Hematologic Malignancies

Role: lead

NCT01549106Phase 1Completed

IPI-145 Single Ascending, Multiple Ascending, Food Effect and Drug-Drug-Interaction Study

Role: lead

NCT02576275Phase 3Withdrawn

A Study of Duvelisib in Combination With Rituximab and Bendamustine vs Placebo in Combination With Rituximab and Bendamustine in Subjects With Previously-Treated Indolent Non-Hodgkin Lymphoma (BRAVURA)

Role: lead

NCT02095587Phase 1Completed

Duvelisib in Hepatically Impaired Subjects Compared to Healthy Subjects

Role: lead

NCT01851707Phase 2Completed

A Double-Blind Study Evaluating Duvelisib in Subjects With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate Alone

Role: lead