Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 90/100

Failure Rate

27.8%

5 terminated/withdrawn out of 18 trials

Success Rate

50.0%

-36.5% vs industry average

Late-Stage Pipeline

17%

3 trials in Phase 3/4

Results Transparency

0%

0 of 5 completed trials have results

Key Signals

4 recruiting

Enrollment Performance

Analytics

Phase 1
9(56.3%)
Phase 3
3(18.8%)
Phase 2
3(18.8%)
Early Phase 1
1(6.3%)
16Total
Phase 1(9)
Phase 3(3)
Phase 2(3)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (18)

Showing 18 of 18 trials
NCT07154706Phase 3Recruiting

Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

Role: lead

NCT06564324Phase 3Recruiting

A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients

Role: lead

NCT05577416Early Phase 1Completed

A Study of AB-218 in Patients With IDH1 Mutated Low Grade Glioma

Role: collaborator

NCT05303519Phase 3Recruiting

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

Role: lead

NCT04395677Phase 2Active Not Recruiting

A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene

Role: lead

NCT04617054Phase 2Terminated

Phase II Study of AB-106 to Treat Patients With Solid Tumors With NTRK Gene Fusion

Role: lead

NCT06334432Phase 1Active Not Recruiting

Safety and Efficacy Study of NUV-1511 in Adult Patients With Advanced Solid Tumors

Role: lead

NCT04919811Phase 2Active Not Recruiting

Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

Role: lead

NCT06841874Unknown

Expanded Access Program of Taletrectinib in Patients With Advanced or Metastatic ROS1-Positive NSCLC

Role: lead

NCT04151342Recruiting

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

Role: collaborator

NCT05252390Phase 1Terminated

NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors

Role: lead

NCT02279433Phase 1Completed

A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b

Role: lead

NCT05609929Phase 1Completed

Study the Effect of Omeprazole on AB-106 Pharmacokinetics

Role: lead

NCT05357820Phase 1Completed

A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK

Role: lead

NCT05357911Phase 1Completed

A Study on the Effect of AB-106 on the Pharmacokinetics of Digoxin

Role: lead

NCT04541225Phase 1Terminated

Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors

Role: lead

NCT05191004Phase 1Withdrawn

Study of NUV-422 in Combination With Fulvestrant in Patients With HR+HER2- aBC

Role: lead

NCT05191017Phase 1Withdrawn

Study of NUV-422 in Combination With Enzalutamide in Patients With mCRPC

Role: lead

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