Phase II Study of AB-106 to Treat Patients With Solid Tumors With NTRK Gene Fusion

NCT04617054 | Terminated Phase 2

• 1 other identifier: AB-106-C205
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

AB-106 will be administered once a day. Each treatment cycle is defined as 21 days of continuous medication. Dosing will continue until any of the following conditions are met: disease progression, intolerable drug-related adverse events, researchers recommend discontinuation of treatment, withdrawal of informed consent, pregnancy during the study, use of other anti-tumor therapy, loss of follow-up, death and other causes, whichever occurs first. The study includes a screening period, treatment period, safety follow-up and long-term follow-up.

Conditions

Solid Tumor

Outcome Measures

Primary Outcomes (1)

• Objective response rate (ORR)

  Assessed by an Independent Review Committee (IRC) based on the RECIST 1.1 criteria or the RANO criteria.

  Approximately 24 months

Secondary Outcomes (12)

• Objective response rate (ORR)

  Approximately 24 months

• Duration of response (DOR)

  Approximately 24 months

• Time to Response (TTR)

  Approximately 24 months

• Time to Progress (TTP)

  Approximately 24 months

• Disease control rate (DCR)

  Approximately 24 months

Study Arms (1)

Single-arm trial whereby all consented, enrolled, eligible patients receive AB-106

EXPERIMENTAL

Drug: AB-106

Interventions

AB-106 DRUG

600mg QD for each subjects.

Single-arm trial whereby all consented, enrolled, eligible patients receive AB-106

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with locally advanced or metastatic solid tumors harboring NTRK1, NTRK2, or NTRK3 fusion genes (anticipated to translate into fusion proteins with a functional TrkA/B/C kinase domain);
• Participants who had failed standard of care or refused standard of care;
• Participants must have had at least 1 measurable lesion as defined by RECIST 1.1;
• For participants diagnosed with a primary CNS tumor, the following criteria should have been met:
• Must have received previous treatment, including radiotherapy (with clear progression before C1D1), chemotherapy, and targeted therapy (completed at least 4 weeks before C1D1).
• At least 1 lesion must be measurable in two dimensions (confirmed by MRI and assessable as per RANO criteria), and each dimension of at least 1 measurable lesion must be ≥1 cm, and can be observed on more than 1 imaging slice.
• Male or female participants ≥18 years old;
• ECOG PS score of ≤1;
• The Investigator judged that the participant's life expectancy was more than 3 months;
• Within 7 days prior to enrollment, laboratory tests had to meet the following criteria (requiring no blood or blood product transfusion, no use of hematopoietic stimulants, or other medications to correct blood cells within 14 days prior to enrollment):
• Absolute neutrophil count ≥1.5×109/L, platelets ≥80×109/L, and hemoglobin ≥90 g/L.
• Serum AST and serum ALT ≤2.5×the upper limit of normal (ULN); AST and ALT ≤5×ULN for participants with liver tumors.
• Total bilirubin ≤1.5×ULN. Participants with a known history of Gilbert's syndrome and an abnormal increase in indirect bilirubin are eligible.
• Serum creatinine ≤2.0×ULN; urine dipstick for urine protein \<2+; if ≥2+, a 24-hour urine protein should be quantified and total urine protein \<1 g.
• Coagulation: International normalized ratio (INR) ≤1.5, and partial prothrombin time or activated partial thromboplastin time (APTT) ≤1.5×ULN;

You may not qualify if:

• Underwent treatment in another therapeutic clinical study within 4 weeks prior to the first dose of taletrectinib;
• Participants who had suffered a cerebrovascular accident (excluding transient ischemic attacks) within 3 months before enrollment;
• Participants with Grade ≥2 toxicity reactions from previous treatments which did not resolve, except for AEs deemed as not posing a safety risk (such as alopecia, neuropathy, and specific laboratory test abnormalities);
• Participants with symptomatic or unstable brain metastases (participants with asymptomatic brain metastases may be eligible), and those with primary CNS tumors may be included if their condition was stable for at least 7 days;
• Participants who underwent major surgery or radiotherapy within 28 days prior to enrollment (participants who received palliative radiotherapy for bone metastasis pain and brain metastasis radiotherapy within 2 weeks before enrollment were allowed to participate), or participants who were expected to require major surgery during the study;
• Known interstitial lung disease, interstitial fibrosis, or pneumonitis induced by tyrosine kinase inhibitors;
• Participants with active, uncontrollable systemic bacterial, viral, or fungal infections, or diseases such as diabetes or hypertension unmanageable with medication, or other systemic diseases that would hinder compliance with the study procedures;
• Active hepatitis B or C infection (HBsAg positive and/or HBcAb positive with HBV DNA ≥104 copies or ≥2000 IU/mL; HCV antibody positive and HCV-RNA positive or HCV-RNA\>ULN);
• History of immunodeficiency, including testing positive for HIV or suffering from other acquired or congenital immunodeficiency diseases, or history of organ transplantation;
• Participants who were expected to use systemic strong inhibitors of CYP3A4 within 28 days prior to the start of the study drug and/or during the study period, including, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin, voriconazole, or strong inducers of CYP3A4, including but not limited to carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, and St. John's Wort, or strong inducers or inhibitors of p-gp;
• Participants with a history of other malignancies. This did not include those who were cured of non-melanoma skin cancer, carcinoma in situ of the cervix, or prostate intraepithelial neoplasm. Participants diagnosed with other malignancies more than 5 years before enrollment could be included only if: (i) there were no active lesions, (ii) the Investigator assessed the risk of recurrence as low, and (iii) the condition would not interfere with the assessment of the efficacy of taletrectinib;
• Participants who, in the Investigator's judgment, had other serious acute or chronic physical illnesses, mental illnesses, or laboratory abnormalities, as well as diseases or abnormalities that might pose an excessive risk in relation to participation in the study or administration of the study drug;
• Expected to use any other antitumor drugs within 14 days prior to starting the study drug and/or during the study, including traditional Chinese medicines, Chinese patent drugs, and herbal medicines (including decoctions) with clear antitumor indications in the package inserts;
• Participants with a known history of neurological or psychiatric disorders, such as epilepsy or dementia, that may affect compliance;
• Participants with a history of drug or substance abuse;

Sponsors & Collaborators

• Nuvation Bio Inc.: lead
• AnHeart Therapeutics Inc.: collaborator

Study Sites (1)

Chinese PLA General Hospital

Beijing, China

Location

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 30, 2020
• First Posted: November 5, 2020
• Study Start: June 1, 2021
• Primary Completion: December 6, 2024
• Study Completion: December 6, 2024
• Last Updated: January 21, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)