Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

47.3%

43 terminated/withdrawn out of 91 trials

Success Rate

29.5%

-57.0% vs industry average

Late-Stage Pipeline

7%

6 trials in Phase 3/4

Results Transparency

144%

26 of 18 completed trials have results

Key Signals

10 recruiting26 with results17 terminated26 withdrawn

Enrollment Performance

Analytics

Phase 1
53(60.2%)
Phase 2
29(33.0%)
Phase 3
6(6.8%)
88Total
Phase 1(53)
Phase 2(29)
Phase 3(6)

Activity Timeline

Global Presence

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Clinical Trials (91)

Showing 20 of 91 trials
NCT07756593Phase 1Not Yet Recruiting

Sipuleucel-T (Sip-T) in Combination With N-803 in Metastatic Androgen Pathway Modulation Resistant (mAPMR) Prostate Cancer

Role: collaborator

NCT06239220Phase 2Recruiting

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

Role: collaborator

NCT06745908Phase 3Recruiting

Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In

Role: lead

NCT04340596Phase 1Active Not Recruiting

Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption

Role: collaborator

NCT03317158Phase 1Active Not Recruiting

Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder

Role: collaborator

NCT06334991Phase 1Active Not Recruiting

Study for Participants With Relapsed/Refractory Non-Hodgkin Lymphoma

Role: lead

NCT07355205Phase 1Recruiting

First-Line Ipilimumab Plus Nivolumab and Nogapendekin Alfa Inbakicept (N-803) in Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer

Role: collaborator

NCT06061809Phase 2Active Not Recruiting

N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma

Role: lead

NCT06710288Phase 2Recruiting

A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer

Role: lead

NCT02782546Phase 2Active Not Recruiting

Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation

Role: collaborator

NCT07524257Phase 3Withdrawn

Phase 3 Study of Nogapendekin Alfa Inbakicept Plus Standard of Care vs Standard of Care in First-Line Advanced or Metastatic NSCLC

Role: lead

NCT07628062Phase 2Not Yet Recruiting

Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation

Role: lead

NCT03520686Phase 3Terminated

Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer

Role: lead

NCT07551544Phase 3Withdrawn

ANKTIVA Plus BCG Versus BCG Monotherapy In Participants With BCG-Naïve/BCG-Exposed High-Grade Non-Muscle Invasive Papillary Bladder Cancer

Role: lead

NCT06810141Unknown

ResQ132EX-NMIBC: Expanded Access Use of Recombinant Bacillus Calmette-Guérin in Nonmuscle Invasive Bladder Cancer

Role: lead

NCT07123727Phase 2Recruiting

A Study to Examine Anktiva for the Treatment of COVID-19.

Role: lead

NCT07108036Phase 2Recruiting

A Study to Assess Anktiva in Patients With Long Covid-19.

Role: lead

NCT07578558Phase 2Not Yet Recruiting

NAI for Sepsis With Persistent Lymphopenia

Role: lead

NCT07492875Phase 3Withdrawn

Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia

Role: lead

NCT07492888Phase 2Withdrawn

Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)

Role: lead