NCT06810141

Brief Summary

This expanded access protocol is designed to provide Recombinant Mycobacterium BCG (rMBCG) to patients with Non-muscle invasive bladder cancer (NMIBC) who are eligible to receive TICE® BCG, may benefit from its use, and who are ineligible to participate in a clinical trial using rMBCG, or for other reasons cannot participate (eg, geographically unable to access a study site).

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

62 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 30, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 5, 2025

Completed
Last Updated

March 27, 2026

Status Verified

January 1, 2026

First QC Date

January 30, 2025

Last Update Submit

March 26, 2026

Conditions

Interventions

rMBCGBIOLOGICAL

1-19.2e8 colony-forming units (CFU) of rMBCG

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥18 years old.
  • Histologic confirmation of non-muscle invasive bladder cancer of the transitional cell carcinoma high-grade subtype (mixed histology tumors allowed if transitional cell histology is predominant histology).
  • Ineligible to participate in a clinical trial using rMBCG or geographically unable to access a rMBCG clinical trial site.
  • Voluntary written informed consent and agreement to comply with all protocol specified procedures and follow-up evaluations.

You may not qualify if:

  • Participants with any of the following criteria are excluded from participation in the study:
  • Other illness or condition, including laboratory abnormalities, which in the opinion of the Investigator would exclude the participant from participating in this study. This includes, but is not limited to, serious medical conditions or psychiatric illness likely to interfere with participation in the study.
  • Women who are pregnant or nursing. Female participants of childbearing potential must have a negative pregnancy test and must adhere to using a medically acceptable method of birth control prior to screening and agree to continue its use during the study and for 30 days after the last dose of study drug, or be surgically sterilized (eg, hysterectomy or tubal ligation). Women of childbearing potential are defined as any female who has experienced menarche and who is NOT permanently sterile or postmenopausal. Postmenopausal is defined as 12 consecutive months with no menses without an alternative medical cause. Males must agree to use barrier methods of birth control while on study and for 90 days post last dose of study drug.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (62)

Urology Centers of Alabama

Homewood, Alabama, 35209, United States

AVAILABLE

University Urology

Mobile, Alabama, 36606, United States

AVAILABLE

Urology Associates

Mobile, Alabama, 36607, United States

AVAILABLE

Mayo Clinic

Phoenix, Arizona, 85054, United States

AVAILABLE

Center for Neurosciences

Tucson, Arizona, 85718, United States

AVAILABLE

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

AVAILABLE

USC/ Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

AVAILABLE

Urology Center of Southern California

Murrieta, California, 92563, United States

AVAILABLE

Saint John's Cancer Institute (Providence)

Santa Monica, California, 90404, United States

AVAILABLE

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

AVAILABLE

Broward Urology Center

Fort Lauderdale, Florida, 33316, United States

AVAILABLE

Genesis Care

Fort Myers, Florida, 33908, United States

AVAILABLE

Mayo Clinic

Jacksonville, Florida, 32224, United States

AVAILABLE

Cohen Urology

Lake Worth, Florida, 33449, United States

AVAILABLE

Sebring Urology Center

Sebring, Florida, 33870, United States

AVAILABLE

Florida Urology Partners

Tampa, Florida, 33615, United States

AVAILABLE

Albany Urology Clinic and Surgery Center

Albany, Georgia, 31707, United States

AVAILABLE

Emory University

Atlanta, Georgia, 30322, United States

AVAILABLE

Georgia Urology

Atlanta, Georgia, 30328, United States

AVAILABLE

Augusta Urology Associates, LLC

Evans, Georgia, 30809, United States

AVAILABLE

Hawaii Cancer Care

Honolulu, Hawaii, 96813, United States

AVAILABLE

Island Urology Oahu

Honolulu, Hawaii, 96813, United States

AVAILABLE

North Idaho Urology, PLLC

Coeur d'Alene, Idaho, 83814, United States

AVAILABLE

The Urology Clinic

Meridian, Idaho, 83642, United States

AVAILABLE

Advanced Urology Skokie

Skokie, Illinois, 60077, United States

AVAILABLE

Urology of Indiana

Carmel, Indiana, 46032, United States

AVAILABLE

US Urology Partners - Carmel

Greenwood, Indiana, 46143, United States

AVAILABLE

First Urology, P.S.C

Jeffersonville, Indiana, 47130, United States

AVAILABLE

Kansas City Urology Care, PA

Lenexa, Kansas, 66214, United States

AVAILABLE

Wichita Urology

Wichita, Kansas, 67226, United States

AVAILABLE

Louisiana Healthcare Associates

Covington, Louisiana, 70433, United States

AVAILABLE

NRMC Urology Associates

Natchitoches, Louisiana, 71457, United States

AVAILABLE

Willis Knighton Urologic Oncology at Pierremont

Shreveport, Louisiana, 71115, United States

AVAILABLE

Pioneer Valley Urology, P.C.

Springfield, Massachusetts, 01107, United States

AVAILABLE

Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

AVAILABLE

Comprehensive Urology

Waterford, Michigan, 48328, United States

AVAILABLE

Essentia Health - Duluth Clinic

Duluth, Minnesota, 55805, United States

AVAILABLE

Allina Health Cancer Institute- Abbott Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

AVAILABLE

Minnesota Urology

Woodbury, Minnesota, 55125, United States

AVAILABLE

Cancer Partners of Nebraska

Lincoln, Nebraska, 68156, United States

AVAILABLE

The Urology Center, P. C. D/B/A/ UroHealth Partners

Omaha, Nebraska, 68114, United States

AVAILABLE

University Urology of NJ

Hamilton, New Jersey, 08690, United States

AVAILABLE

Advance Urology Associates Enterprises/ HLP Urology Associates

Manasquan, New Jersey, 08736, United States

AVAILABLE

Garden State Urology

Morristown, New Jersey, 07960, United States

AVAILABLE

Capital Health Urology

Pennington, New Jersey, 08534, United States

AVAILABLE

NYU Langone Health

New York, New York, 10016, United States

AVAILABLE

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

AVAILABLE

Advanced Urology, Center for Robotic Surgery

Leland, North Carolina, 28451, United States

AVAILABLE

Cleveland Clinic

Garfield Heights, Ohio, 44125, United States

AVAILABLE

Department of Urology, Jefferson Einstein Hospital

Philadelphia, Pennsylvania, 19141, United States

AVAILABLE

Center for Urologic Care of Berks County

Wyomissing, Pennsylvania, 19610, United States

AVAILABLE

Urology Associates of Charleston

Mt. Pleasant, South Carolina, 29464, United States

AVAILABLE

AUC Urologists, LLC

Myrtle Beach, South Carolina, 29572, United States

AVAILABLE

Erlanger Health, Inc.

Chattanooga, Tennessee, 37403, United States

AVAILABLE

The West Clinic, PLLC dba West Cancer Center

Germantown, Tennessee, 38138, United States

AVAILABLE

The University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States

AVAILABLE

Rio Grande Urology

El Paso, Texas, 79912, United States

AVAILABLE

The Urology Place

San Antonio, Texas, 78240, United States

AVAILABLE

Danville Urologic Clinic

Danville, Virginia, 24541, United States

AVAILABLE

Potomac Urology

Fairfax, Virginia, 22033, United States

AVAILABLE

Virginia Urology

Richmond, Virginia, 23235, United States

AVAILABLE

Valley Health Urology

Winchester, Virginia, 22601, United States

AVAILABLE

MeSH Terms

Conditions

Non-Muscle Invasive Bladder Neoplasms

Condition Hierarchy (Ancestors)

CarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsUrinary Bladder NeoplasmsUrologic NeoplasmsUrogenital NeoplasmsNeoplasms by SiteFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrinary Bladder DiseasesUrologic DiseasesMale Urogenital Diseases

Central Study Contacts

Study Design

Study Type
expanded access
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 30, 2025

First Posted

February 5, 2025

Last Updated

March 27, 2026

Record last verified: 2026-01

Locations