Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
TRAVELLER
Master Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies as Assessed by Biomarker Status and Cognition
1 other identifier
interventional
13,000
14 countries
207
Brief Summary
This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jul 2025
Longer than P75 for phase_3
207 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 2, 2025
CompletedFirst Submitted
Initial submission to the registry
September 15, 2025
CompletedFirst Posted
Study publicly available on registry
September 17, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2035
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2035
March 9, 2026
March 1, 2026
10.1 years
September 15, 2025
March 6, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Concentration of pTau217 in Blood on Day1
Day 1
Cognitive score in ISLT on Day 1
Day 1
Study Arms (1)
Screening Arm
OTHERParticipants will be assessed for their concentration of pTau217 in blood and cognitive score in the International Shopping List Test (ISLT).
Interventions
Participants will have their blood drawn and cognitive score measured by the ISLT.
Eligibility Criteria
You may qualify if:
- \- Report of objective or subjective memory concerns (by the participant and/or their informant) within the last year with or without a previous clinical diagnosis of MCI or dementia due to AD.
You may not qualify if:
- Dependency in basic activities of daily living (bADLs) due to cognitive impairment
- Visual or auditory impairment that would prevent them from performing the cognitive assessments (eyeglasses and hearing aids are permitted)
- Any self-reported evidence or known diagnosis of a neurological or neurodegenerative condition that may lead to cognitive impairment other than AD
- History of severe, clinically significant central nervous system trauma
- Any serious medical condition that precludes a participant's safe participation and completion of a clinical study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (207)
Banner Alzheimer?s Institute
Phoenix, Arizona, 85006, United States
Banner Sun Health Research Institute
Sun City, Arizona, 85351, United States
Sun Valley Research Center, Inc.
Imperial, California, 92251, United States
Inglewood Clinicals
Inglewood, California, 90301, United States
Irvine Center for Clinical Research
Irvine, California, 92614, United States
Healthy Brain Clinic
Long Beach, California, 90804, United States
Oakland Clinical
Oakland, California, 94609, United States
Riverside Clinical
Riverside, California, 92506, United States
Syrentis Clinical Research
Santa Ana, California, 92705, United States
Cenexel California Neuroscience Research, LLC
Sherman Oaks, California, 91403, United States
Yale University
New Haven, Connecticut, 06510, United States
JEM Research LLC
Atlantis, Florida, 33462, United States
K2 Medical Research-Winter Garden
Clermont, Florida, 34711, United States
K2 Medical Research - The Villages
Lady Lake, Florida, 32159, United States
K2 Medical Research, LLC
Maitland, Florida, 32751, United States
Visionary Investigators Network- Neurology Aventura
Miami, Florida, 33133, United States
Renstar Medical Research
Ocala, Florida, 34470, United States
Charter Research - Winter Park/Orlando
Orlando, Florida, 32803, United States
Conquest Research - Lake Nona
Orlando, Florida, 32832, United States
Alzheimer's Research and Treatment Center
Stuart, Florida, 34997, United States
Axiom Brain Health LLC
Tampa, Florida, 34654, United States
Charter Research - Lady Lake/The Villages
The Villages, Florida, 32162, United States
Alzheimer?s Research and Treatment Center
Wellington, Florida, 33414, United States
Conquest Research, LLC
Winter Park, Florida, 32789, United States
Grady Memorial Hospital
Atlanta, Georgia, 30303, United States
Alzheimer's Research and Treatment Center - Columbus
Columbus, Georgia, 31904, United States
Accel Research Sites-NeuroStudies
Decatur, Georgia, 30030, United States
CenExel iResearch, LLC
Decatur, Georgia, 30030, United States
Center for Advanced Research & Education
Gainesville, Georgia, 30501, United States
Hawaii Pacific Neuroscience
Honolulu, Hawaii, 96817, United States
RE:Cognition (Chicago)
Chicago, Illinois, 60611, United States
Great Lakes Clinical Trials Chicago d/b/a Flourish Research Andersonville
Chicago, Illinois, 60640, United States
Tandem Clinical Research, LLC
Marrero, Louisiana, 70072, United States
Adams Clinical Boston
Boston, Massachusetts, 02116, United States
Boston Center for Memory
Newton, Massachusetts, 02459, United States
Adams Clinical Watertown
Watertown, Massachusetts, 02472, United States
Quest Research Institute
Farmington Hills, Michigan, 48334, United States
Washington University School of MedicineClinical Translational Research Unit
St Louis, Missouri, 63110, United States
The Cognitive and Research Center of New Jersey
Ridgewood, New Jersey, 07450, United States
The Cognitive and Research Center of New Jersey
Springfield, New Jersey, 07081, United States
IMA Clinical Research - Albuquerque
Albuquerque, New Mexico, 87109, United States
Basil Clinical
Laurelton, New York, 11413-2016, United States
Weill Cornell Medical College
New York, New York, 10021, United States
Adams Clinical Harlem
New York, New York, 10029, United States
AD-CARE, University of Rochester Medical Center
Rochester, New York, 14620, United States
Adams Clinical Bronx
The Bronx, New York, 10461, United States
Triad Clinical Trials
Greensboro, North Carolina, 27410, United States
Ohio State University
Columbus, Ohio, 43221, United States
Summit Research Network Inc.
Portland, Oregon, 97210, United States
Flourish Research ? Philadelphia
Plymouth Meeting, Pennsylvania, 19462, United States
Butler Hospital
Providence, Rhode Island, 02906, United States
Ralph H. Johnson VA Medical Center
Charleston, South Carolina, 29403, United States
Palmetto Clinical Trials
Summerville, South Carolina, 29485, United States
Genesis Neuroscience Clinic
Knoxville, Tennessee, 37909, United States
K2 Medical Research - Nashville
Nashville, Tennessee, 37204, United States
Gadolin Research, LLC
Beaumont, Texas, 77702, United States
South Texas Research Institute - Brownsville
Brownsville, Texas, 78520, United States
Kerwin Medical Center
Dallas, Texas, 75216, United States
Kerwin Research Center, LLC
Dallas, Texas, 75231, United States
South Texas Research Institute - Edinburg
Edinburg, Texas, 78539, United States
Re:Cognition Health - Fort Worth
Fort Worth, Texas, 76104, United States
Re:Cognition Health - Houston
Houston, Texas, 77030, United States
Mt.Olympus Medical Research
Katy, Texas, 77450, United States
El Faro Health and Therapeutics
Rio Grande City, Texas, 78582, United States
Sana Research, LLC
Arlington, Virginia, 22205, United States
Re:Cognition Health
Fairfax, Virginia, 22031, United States
National Clinical Research Inc.-Richmond
Richmond, Virginia, 23294, United States
INECO Neurociencias Orono
Rosario, Santa Fe Province, S2000DTC, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, C1181ACH, Argentina
Fundacion Scherbovsky
Mendoza, 5500, Argentina
Sanatorio del Sur S.A.
San Miguel de Tucumán, T4000IDK, Argentina
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
St Vincent's Hospital Sydney
Darlinghurst, New South Wales, 2010, Australia
Southern Neurology
Kogarah, New South Wales, 2217, Australia
KaRa Institute of Neurological Diseases
Macquarie Park, New South Wales, 2113, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Queen Elizabeth Hospital
Woodville, South Australia, 5011, Australia
Box Hill Hospital
Box Hill, Victoria, 3128, Australia
Heidelberg Repatriation Hospital
Heidelberg, Victoria, 3081, Australia
Alfred Health
Melbourne, Victoria, 3004, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Instituto de Neurologia de Curitiba
Curitiba, Paraná, 81210-310, Brazil
Clinica Clinilive ltda
Maringá, Paraná, 87013-250, Brazil
Hospital das Clinicas - UFRGS
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Instituto do Cerebro do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Clinica Neurologica
Joinville, Santa Catarina, 89202-190, Brazil
Centro Multidisciplinar de Estudos Clínicos - CEMEC*X*
São Bernardo do Campo, São Paulo, 09715-090, Brazil
Centro de Pesquisas Clinicas - CPCLIN
São Paulo, São Paulo, 01244-030, Brazil
Okanagan Clinical Trials
Kelowna, British Columbia, V1Y 1Z9, Canada
Richmond Clinical Trials
Richmond, British Columbia, V6V 2L1, Canada
Centricity Research
Halifax, Nova Scotia, B3S 1N2, Canada
Parkwood Institute, Mental Health Care Building
London, Ontario, N6C 0A7, Canada
Bruyère Health Research Institute
Ottawa, Ontario, K1N 5C8, Canada
The Ottawa Memory Clinic
Ottawa, Ontario, K1Z 1G3, Canada
Kawartha Regional Memory Clinic
Peterborough, Ontario, K9H 2P4, Canada
Toronto Memory Program
Toronto, Ontario, M3B 2S7, Canada
Centricity East York
Toronto, Ontario, M4G 3E8, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
Baycrest Health Sciences
Toronto, Ontario, M6A 2E1, Canada
Clinique Memoire de Montreal
Montreal, Quebec, H2X 3B9, Canada
Genge Partners Inc.
Montreal, Quebec, H4A 3T2, Canada
Alpha Recherche Clinique
Québec, G3K 2P8, Canada
Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, 221002, China
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
Beijing, 100050, China
The First Hospital of Jilin University
Changchun, 130021, China
West China Hospital - Sichuan University
Chengdu, 610047, China
The First Affiliated Hospital, Chongqing Medical University
Chongqing, 400016, China
The second Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510000, China
Guangdong General Hospital
Guangzhou, 510080, China
The First Affiliated Hospital of Anhui Medical University
Hefei, 230022, China
Zhongda Hospital Affiliated to Southeast University
Nanjing, 210009, China
Nanjing Brain Hospital
Nanjing, 210029, China
Nanjing First Hospital
Nanjing, 210029, China
Huashan Hospital, Fudan University
Shanghai, 200040, China
Shanghai First People's Hospital
Shanghai, 200080, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, 200127, China
The Second Affiliated Hospital of Soochow University
Suzhou, 215004, China
Aalborg Universitetshospital
Aalborg, 9000, Denmark
Aarhus Universitetshospital Skejby
Aarhus N, 8200, Denmark
Rigshospitalet, Hukommelsesklinikken
København Ø, 2100, Denmark
A. O. U. Federico II
Naples, Campania, 80131, Italy
Policlinico Universitario Agostino Gemelli
Rome, Lazio, 00168, Italy
Fondazione Santa Lucia IRCCS
Rome, Lazio, 00179, Italy
Umberto I Policlinico di Roma-Università di Roma La Sapienza
Rome, Lazio, 00185, Italy
Ospedale Isola Tiberina - Gemelli Isola
Rome, Lazio, 00186, Italy
Irccs A.O.U.San Martino Ist
Genoa, Liguria, 16132, Italy
Asst Degli Spedali Civili Di Brescia
Brescia, Lombardy, 25100, Italy
IRCCS Ospedale San Raffaele
Milan, Lombardy, 20132, Italy
AOU Policlinico Giaccone
Palermo, Sicily, 90129, Italy
AO di Perugia - Ospedale S. Maria della Misericordia
Perugia, Umbria, 06156, Italy
Brain Attack Center Ota Memorial Hospital
Hiroshima, 720-0825, Japan
National Hospital Organization Hiroshima-Nishi Medical Center
Hiroshima, 739-0696, Japan
Kobe University Hospital
Hyōgo, 650-0017, Japan
Kagawa University Hospital
Kagawa, 761-0793, Japan
Kochi Medical School Hospital
Kochi, 783-8505, Japan
Kyoto University Hospital
Kyoto, 606-8507, Japan
National Hospital Organization Utano National Hospital
Kyoto, 616-8255, Japan
Mishuku Hospital
Meguro-Ku, 153-0051, Japan
Mie University Hospital
Mie, 514-8507, Japan
Okayama City Hospital
Okayama, 700-8557, Japan
Rijikai Medical Corporation Katayama Medical Clinic
Okayama, 710-0813, Japan
Kotobuki Social Medical Corporation Tominaga Clinic
Osaka, 556-0015, Japan
Memory Clinic Ochanomizu
Tokyo, 113-0034, Japan
The University of Tokyo Hospital
Tokyo, 113-8655, Japan
Keio University Hospital
Tokyo, 160-8582, Japan
Higashi-Shinjuku Clinic
Tokyo, 169-0072, Japan
Tokyo Metropolitan Geriatric Hospital
Tokyo, 173-0015, Japan
National Center of Neurology and Psychiatry
Tokyo, 187-8551, Japan
Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital
Tokyo, 190-8531, Japan
P-One Clinic
Tokyo, 192-0071, Japan
Yamagata Tokusyukai Hospital
Yamagata, 990-0834, Japan
ProNeuro Centrum Medyczne
?ory, 44-240, Poland
Uniwersytet Medyczny w Lodzi
?ód?, 92-216, Poland
Syberka-ClinHouse Sp. z o.o.
B?dzin, 42-500, Poland
Podlaskie Centrum Psychogeriatrii
Bia?ystok, 15-756, Poland
Centrum Medyczne Neuromed Sp. z.o.o.
Bydgoszcz, 85-163, Poland
Centrum Badan Klinicznych PI-House sp. z o.o.
Gda?sk, 80-546, Poland
Uniwersyteckie Centrum Kliniczne;Klinika Neurologii Doros?ych
Gdansk, 80-214, Poland
Neuro-Care Gabriela Klodowska
Katowice, 40-749, Poland
Szpital Uniwersytecki w Krakowie
Krakow, 30-688, Poland
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K
Krakow, 31-505, Poland
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
Lublin, 20-410, Poland
Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka Komandytowa
Późna, 61-731, Poland
Nmedis sp. z o.o.
Rzeszów, 35-323, Poland
Centrum Medyczne Medyk
Rzeszów, 35-326, Poland
Senior Sp. Z O.O. Poradnia Psychogeriatryczna
Sopot, 81-855, Poland
O?rodek Badawczo-Naukowo-Dydaktyczny Chorób Ot?piennych w ?cinawie
Ścinawa, 59-330, Poland
Centrum Medyczne NeuroProtect
Warsaw, 01-684, Poland
ETG Neuroscience Sp. z o.o.
Warsaw, 02-677, Poland
Centrum Leczenia Zaburzen Pamieci
Warsaw, 03-839, Poland
NZOZ WCA
Wroc?aw, 53-659, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach
Zabrze, 41-800, Poland
University of Puerto Rico - Medical Science Campus
San Juan, 00935, Puerto Rico
Chonnam National University Hospital
Gwangju, 61469, South Korea
St. Vincent's Hospital
Gyeonggi-do, 442-723, South Korea
Inha University Hospital
Incheon, 22332, South Korea
Gachon University Gil Medical Center
Namdong-gu, 21565, South Korea
Seoul National University Bundang Hospital
Seongnam-si, 13605, South Korea
Hanyang University Seoul Hospital
Seoul, 04763, South Korea
Samsung Medical Center
Seoul, 06351, South Korea
Ewha Womans University Hospital (Seoul)
Seoul, 07804, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Asan Medical Center
Seoul, South Korea
Ajou University Medical Center
Suwon, 16499, South Korea
Hospital de Dénia;Servicio de Neurología
Denia, Alicante, 03700, Spain
Fundació Hospitalàries Martorell;Neurology
Martorell, Barcelona, 08760, Spain
Hospital Mutua De Terrasa
Terrassa, Barcelona, 08221, Spain
Hospital Quiron de Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
Fundación ACE
Barcelona, 08028, Spain
Hospital Vall d'Hebron
Barcelona, 08035, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
Hospital Universitario Reina Sofia
Córdoba, 14011, Spain
Policlínica Guipuzkoa
Donosti-San Sebastián, 20014, Spain
Hospital San Cecilio
Granada, 18016, Spain
Hospital Universitario de la Princesa
Madrid, 28006, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Virgen del Rocío
Seville, 41013, Spain
Hospital Universitario Dr. Peset
Valencia, 46017, Spain
Hospital Universitario la Fe
Valencia, 46026, Spain
Kaohsiung Medical University Hospital
Kaohsiung City, 807, Taiwan
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Neurology
Kwei Shen, 33305, Taiwan
Taipei Medical University - Shuang Ho Hospital - Neurology
New Taipei City, 23561, Taiwan
China Medical University Hospital
North Dist., 40447, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Central Study Contacts
Reference Study ID Number: WP45722 https://forpatients.roche.com/
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NA
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 15, 2025
First Posted
September 17, 2025
Study Start
July 2, 2025
Primary Completion (Estimated)
July 31, 2035
Study Completion (Estimated)
July 31, 2035
Last Updated
March 9, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will not share