Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 90/100

Failure Rate

28.6%

6 terminated/withdrawn out of 21 trials

Success Rate

71.4%

-15.1% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

7%

1 of 15 completed trials have results

Key Signals

1 with results

Enrollment Performance

Analytics

Phase 1
16(76.2%)
Phase 2
5(23.8%)
21Total
Phase 1(16)
Phase 2(5)

Activity Timeline

Global Presence

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Clinical Trials (21)

Showing 20 of 21 trials
NCT02673476Phase 2Completed

A Phase 2a Study to Evaluate Orally Administered ALS-008176 in Adults Hospitalized With a Respiratory Syncytial Virus

Role: lead

NCT02094365Phase 2Completed

A Phase 2a Study to Evaluate ALS-008176 in the Virus Challenge Model

Role: lead

NCT02202356Phase 1Completed

A Study of ALS-008176 in Infants Hospitalized With RSV

Role: lead

NCT03439488Phase 1Completed

A Study of Orally Administered JNJ-440 to Evaluate the Safety, Tolerability, and Pharmacokinetics After Single Ascending Doses Including Food Effect Evaluation; After Multi-Day Dosing in Healthy Participants; and After Multiple (Ascending) Doses in Participants With Chronic Hepatitis B

Role: lead

NCT02888327Phase 1Completed

A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872

Role: lead

NCT03411421Phase 1Terminated

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Repeated Dosing Regimens of AL-794 in Healthy Volunteers

Role: lead

NCT03285620Phase 1Completed

A Study of AL-034 to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses in Healthy Participants

Role: lead

NCT02339207Phase 1Completed

First in Human Study of AL-335; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Role: lead

NCT02512562Phase 1Completed

A Study to Evaluate the Effect of ACH-3102 and Simeprevir on AL-335 Pharmacokinetics in Healthy Volunteers

Role: lead

NCT02569710Phase 2Completed

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335, Odalasvir, and Simeprevir

Role: lead

NCT01790100Phase 2Completed

A Phase 2a, Dose-Ranging Study to Evaluate the Safety, Pharmacokinetics and Efficacy of VX-135 With Ribavirin in Treatment-Naïve Subjects With Chronic Hepatitis C

Role: lead

NCT02510248Phase 1Terminated

First in Human Study of AL-704; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C

Role: lead

NCT01590407Phase 1Completed

First in Human Study of ALS-002200; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Role: lead

NCT01554085Phase 1Terminated

First in Human Study of ALS-002158; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Role: lead

NCT01906164Phase 1Completed

Study of Single and Multiple Doses of ALS-008176 in Healthy Volunteers

Role: lead

NCT02231671Phase 1Completed

A Phase 1, Open-Label Study of the Absorption, Metabolism, Excretion and Absolute Bioavailability of ALS-008176

Role: lead

NCT03253471Phase 1Terminated

A First in Human Study of AL-611 in Healthy Volunteers and Patients With Hepatitis C Virus Infection

Role: lead

NCT03125213Phase 2Withdrawn

A Study Evaluating AL-3778 in Combination With Peginterferon Alpha-2a in Chronic Hepatitis B Subjects

Role: lead

NCT03032536Phase 1Terminated

Study of the Relative Oral Bioavailability of AL-3778 Tablets and Drug Interaction With Entecavir or Tenofovir Disoproxil Fumarate in Healthy Volunteers

Role: lead

NCT02588521Phase 1Completed

A Study of AL-794 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses, and the Antiviral Activity of Multiple Doses in an Influenza Challenge Study

Role: lead