Success Metrics

Clinical Success Rate
92.9%

Based on 13 completed trials

Completion Rate
93%(13/14)
Active Trials
0(0%)
Results Posted
31%(4 trials)
Terminated
1(6%)

Phase Distribution

Ph phase_2
4
25%
Ph phase_1
2
13%
Ph phase_4
2
13%
Ph early_phase_1
1
6%
Ph not_applicable
5
31%

Phase Distribution

3

Early Stage

4

Mid Stage

2

Late Stage

Phase Distribution14 total trials
Early Phase 1First-in-human
1(7.1%)
Phase 1Safety & dosage
2(14.3%)
Phase 2Efficacy & side effects
4(28.6%)
Phase 4Post-market surveillance
2(14.3%)
N/ANon-phased studies
5(35.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

86.7%

13 of 15 finished

Non-Completion Rate

13.3%

2 ended early

Currently Active

0

trials recruiting

Total Trials

16

all time

Status Distribution
Completed(13)
Terminated(2)
Other(1)

Detailed Status

Completed13
Withdrawn1
unknown1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
16
Active
0
Success Rate
92.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (7.1%)
Phase 12 (14.3%)
Phase 24 (28.6%)
Phase 42 (14.3%)
N/A5 (35.7%)

Trials by Status

withdrawn16%
unknown16%
completed1381%
terminated16%

Recent Activity

0 active trials
Showing 5 of 16
completednot_applicable

Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions

NCT06939608
withdrawnphase_4

Role Of Sensitivity to neuroEndocrine Systems in Social Decisions

NCT06018727
completedphase_1

Effects of Stress and Drug-cue Exposure (SCM)

NCT03154567
completednot_applicable

The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat

NCT04359147
terminatedearly_phase_1

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

NCT02963181
View all 16 trials

Clinical Trials (16)

Showing 16 of 16 trials
NCT06939608Not Applicable

Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions

Completed
NCT06018727Phase 4

Role Of Sensitivity to neuroEndocrine Systems in Social Decisions

Withdrawn
NCT03154567Phase 1

Effects of Stress and Drug-cue Exposure (SCM)

Completed
NCT04359147Not Applicable

The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat

Completed
NCT02963181Early Phase 1

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

Terminated
NCT02470026Not Applicable

Noradrenergic Activity, Cognition and Major Depressive Disorder

Completed
NCT01031979Phase 2

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine

Completed
NCT00535002Phase 2

The Effect of Yohimbine on Cocaine Cue Reactivity

Completed
NCT00223691Phase 1

Treatment of Orthostatic Hypotension in Autonomic Failure

Completed
NCT02541071Not Applicable

Influence of the Noradrenergic System on the Formation of Intrusive Memories

Completed
NCT00975325Phase 4

Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine

Completed
NCT01593215Phase 2

Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant

Completed
NCT00605904Phase 2

Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics

Completed
NCT01621620Not Applicable

The Role of Sympatho-vagal Balance on Different Limbs of Pain Perception in Healthy Subjects

Unknown
NCT00029627

Brain Receptors in Sympathetic Nervous System Regulation

Completed
NCT00032838

Effects of Stress Hormones on Emotion and Cognition

Completed

All 16 trials loaded

Drug Details

Intervention Type
DIETARY SUPPLEMENT
Total Trials
16