Influence of the Noradrenergic System on the Formation of Intrusive Memories
1 other identifier
interventional
118
1 country
1
Brief Summary
Intrusive memories of traumatic events are core features of posttraumatic stress disorder (PTSD) but little is known about the neurobiological formation of intrusions. The aim of this study was to determine whether the activity of the noradrenergic system during an intrusion-inducing stressor influences subsequent intrusive memories.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Nov 2013
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2014
CompletedFirst Submitted
Initial submission to the registry
August 6, 2015
CompletedFirst Posted
Study publicly available on registry
September 4, 2015
CompletedSeptember 4, 2015
September 1, 2015
11 months
August 6, 2015
September 3, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Number of intrusive memories
Measured with an intrusion diary
four consecutive days
Secondary Outcomes (2)
Vividness of intrusive memories
four consecutive days
Degree of distress of intrusive memories
four consecutive days
Study Arms (3)
Yohimbine and Stress Film
EXPERIMENTALAdministration of 10mg yohimbine before the trauma film.
Placebo and Stress Film
EXPERIMENTALAdministration of placebo before the trauma film.
Clonidine and Stress Film
EXPERIMENTALAdministration of 0.15mg clonidine before the trauma film.
Interventions
Eligibility Criteria
You may qualify if:
- healthy participants
- German on a native level
You may not qualify if:
- former or present DSM IV Axis I disorders
- physical illnesses
- any medication intake (except oral contraceptive)
- history of sexual abuse or rape
- pregnancy or lactation period
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Benjamin Franklin
Berlin, State of Berlin, 12203, Germany
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Stefan Roepke, Dr.
Charite University, Berlin, Germany
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dipl.-Psych.
Study Record Dates
First Submitted
August 6, 2015
First Posted
September 4, 2015
Study Start
November 1, 2013
Primary Completion
October 1, 2014
Study Completion
October 1, 2014
Last Updated
September 4, 2015
Record last verified: 2015-09