Success Metrics

Clinical Success Rate
71.4%

Based on 10 completed trials

Completion Rate
71%(10/14)
Active Trials
71(73%)
Results Posted
160%(16 trials)
Terminated
4(4%)

Phase Distribution

Ph phase_1
24
25%
Ph phase_4
2
2%
Ph phase_3
16
16%
Ph phase_2
43
44%
Ph early_phase_1
1
1%

Phase Distribution

25

Early Stage

43

Mid Stage

18

Late Stage

Phase Distribution86 total trials
Early Phase 1First-in-human
1(1.2%)
Phase 1Safety & dosage
24(27.9%)
Phase 2Efficacy & side effects
43(50.0%)
Phase 3Large-scale testing
16(18.6%)
Phase 4Post-market surveillance
2(2.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.4%

10 of 14 finished

Non-Completion Rate

28.6%

4 ended early

Currently Active

71

trials recruiting

Total Trials

97

all time

Status Distribution
Active(80)
Completed(10)
Terminated(4)
Other(3)

Detailed Status

Recruiting53
Active, not recruiting18
Completed10
Not yet recruiting8
Terminated4
Suspended2

Development Timeline

Analytics

Development Status

Total Trials
97
Active
71
Success Rate
71.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.2%)
Phase 124 (27.9%)
Phase 243 (50.0%)
Phase 316 (18.6%)
Phase 42 (2.3%)

Trials by Status

enrolling_by_invitation11%
active_not_recruiting1819%
completed1010%
suspended22%
terminated44%
recruiting5355%
unknown11%
not_yet_recruiting88%

Recent Activity

Clinical Trials (97)

Showing 20 of 97 trialsScroll for more
NCT07060807Phase 3

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Recruiting
NCT06467357Phase 3

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

Recruiting
NCT06324357Phase 1

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Recruiting
NCT05372614Phase 1

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Suspended
NCT04585958Phase 1

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Recruiting
NCT07137416Phase 1

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

Recruiting
NCT07012031Phase 1

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Recruiting
NCT04616560Phase 2

Trastuzumab Deruxtecan for the Treatment of HER2+ Newly Diagnosed or Recurrent Osteosarcoma

Suspended
NCT06364410Phase 1

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

Recruiting
NCT06311214Phase 2

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Recruiting
NCT04704661Phase 1

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Recruiting
NCT06764875Phase 3

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

Recruiting
NCT04482309Phase 2

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Active Not Recruiting
NCT07198724Phase 1

ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

Recruiting
NCT06989112Phase 3

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Recruiting
NCT05950945Phase 3

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Recruiting
NCT05744375Phase 2

Trastuzumab Deruxtecan in First-line HER2-positive Locally Advanced/MBC Patients Resistant to Trastuzumab+Pertuzumab

Terminated
NCT05480384Phase 2

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Active Not Recruiting
NCT07124000

DESTINY-PANTUMOUR04

Recruiting
NCT04539938Phase 2

A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
97