Success Metrics

Clinical Success Rate
79.3%

Based on 340 completed trials

Completion Rate
79%(340/429)
Active Trials
154(22%)
Results Posted
61%(206 trials)
Terminated
89(13%)

Phase Distribution

Ph early_phase_1
19
3%
Ph not_applicable
12
2%
Ph phase_1
270
39%
Ph phase_2
326
47%
Ph phase_3
60
9%
Ph phase_4
4
1%

Phase Distribution

289

Early Stage

326

Mid Stage

64

Late Stage

Phase Distribution691 total trials
Early Phase 1First-in-human
19(2.7%)
Phase 1Safety & dosage
270(39.1%)
Phase 2Efficacy & side effects
326(47.2%)
Phase 3Large-scale testing
60(8.7%)
Phase 4Post-market surveillance
4(0.6%)
N/ANon-phased studies
12(1.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.2%

340 of 452 finished

Non-Completion Rate

24.8%

112 ended early

Currently Active

154

trials recruiting

Total Trials

701

all time

Status Distribution
Active(169)
Completed(340)
Terminated(112)
Other(80)

Detailed Status

Completed340
Terminated89
Recruiting86
unknown78
Active, not recruiting68
Withdrawn23

Development Timeline

Analytics

Development Status

Total Trials
701
Active
154
Success Rate
79.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 119 (2.7%)
Phase 1270 (39.1%)
Phase 2326 (47.2%)
Phase 360 (8.7%)
Phase 44 (0.6%)
N/A12 (1.7%)

Trials by Status

unknown7811%
completed34049%
not_yet_recruiting152%
withdrawn233%
active_not_recruiting6810%
suspended20%
recruiting8612%
terminated8913%

Recent Activity

Clinical Trials (701)

Showing 20 of 701 trialsScroll for more
NCT05691491Phase 1

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

Recruiting
NCT00268385Phase 1

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Active Not Recruiting
NCT03880019Phase 2

A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Active Not Recruiting
NCT02152982Phase 2

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Active Not Recruiting
NCT03528642Phase 1

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Active Not Recruiting
NCT05902169Phase 3

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Recruiting
NCT03970447Phase 2

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Recruiting
NCT06991101Phase 2

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Recruiting
NCT04555577Phase 1

Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma

Active Not Recruiting
NCT06172296Phase 3

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Recruiting
NCT05781321Phase 2

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

Active Not Recruiting
NCT04337177Phase 1

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Active Not Recruiting
NCT07492680Phase 2

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

Recruiting
NCT07104032Phase 3

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

Recruiting
NCT03899155Phase 2

Pan Tumor Rollover Study

Recruiting
NCT07015242Phase 2

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

Recruiting
NCT03556384Phase 2

Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Completed
NCT04743661Phase 2

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Active Not Recruiting
NCT03180502Phase 2

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Active Not Recruiting
NCT07732413Phase 1

Trial of NLG802 Indoximod Prodrug Plus Temozolomide for Patients With Progressive Pediatric Brain Cancer

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
701