Success Metrics

Clinical Success Rate
40.0%

Based on 8 completed trials

Completion Rate
40%(8/20)
Active Trials
19(41%)
Results Posted
138%(11 trials)
Terminated
12(26%)

Phase Distribution

Ph phase_2
21
46%
Ph phase_3
3
7%
Ph early_phase_1
1
2%
Ph phase_1
21
46%

Phase Distribution

22

Early Stage

21

Mid Stage

3

Late Stage

Phase Distribution46 total trials
Early Phase 1First-in-human
1(2.2%)
Phase 1Safety & dosage
21(45.7%)
Phase 2Efficacy & side effects
21(45.7%)
Phase 3Large-scale testing
3(6.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

34.8%

8 of 23 finished

Non-Completion Rate

65.2%

15 ended early

Currently Active

19

trials recruiting

Total Trials

46

all time

Status Distribution
Active(23)
Completed(8)
Terminated(15)

Detailed Status

Recruiting16
Terminated12
Completed8
Not yet recruiting4
Withdrawn3
Active, not recruiting3

Development Timeline

Analytics

Development Status

Total Trials
46
Active
19
Success Rate
40.0%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (2.2%)
Phase 121 (45.7%)
Phase 221 (45.7%)
Phase 33 (6.5%)

Trials by Status

withdrawn37%
recruiting1635%
active_not_recruiting37%
completed817%
not_yet_recruiting49%
terminated1226%

Recent Activity

Clinical Trials (46)

Showing 20 of 46 trialsScroll for more
NCT07679334Phase 1

Phase I Trial of Pacritinib in Combination With Venetoclax and Azacitidine for the Treatment of Accelerated and Blast Phase Myeloproliferative Neoplasms

Not Yet Recruiting
NCT06303193Phase 1

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

Recruiting
NCT07394153Phase 2

Pacritinib For Bone Marrow Fibrosis In Patients With Myelofibrosis Who Have Thrombocytopenia

Recruiting
NCT06538181Phase 1

Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

Recruiting
NCT05531786Phase 1

Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Recruiting
NCT07387354Phase 1

Pacritinib With Aza for Upfront Myelodysplastic Syndrome

Not Yet Recruiting
NCT06052618Phase 2

Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)

Recruiting
NCT06516887Phase 1

Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma

Terminated
NCT06414681Early Phase 1

Combination of Tagraxofusp With Pacritinib in Patients With Intermediate-1 or Higher Myelofibrosis, Who Have Had Prior Therapy With the Approved JAK Inhibitors or in Which Therapy With the Approved JAK Inhibitors is Not Appropriate, Contraindicated or Declined

Recruiting
NCT07226713Phase 2

Pacritinib in Participants With Metastatic Castrate-Resistant Prostate Cancer That Progressed on or After Prior Treatment With Androgen Receptor Signaling Inhibitors

Not Yet Recruiting
NCT03165734Phase 3

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Active Not Recruiting
NCT06782373Phase 2

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

Recruiting
NCT02891603Phase 1

A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression

Completed
NCT07447817Phase 2

Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias

Not Yet Recruiting
NCT04282187Phase 2

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT07033598Phase 2

Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia

Recruiting
NCT07148947Phase 2

Pacritinib With Standard of Care Azacitidine or Decitabine as a Bridge to Allogeneic Hematopoietic Stem Cell Transplant for Patients With Accelerated and Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT05980806Phase 2

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Recruiting
NCT04858256Phase 2

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

Recruiting
NCT06986174Phase 2

A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
46