Success Metrics

Clinical Success Rate
42.1%

Based on 8 completed trials

Completion Rate
42%(8/19)
Active Trials
20(44%)
Results Posted
138%(11 trials)
Terminated
11(24%)

Phase Distribution

Ph early_phase_1
1
2%
Ph phase_3
3
7%
Ph phase_1
20
44%
Ph phase_2
21
47%

Phase Distribution

21

Early Stage

21

Mid Stage

3

Late Stage

Phase Distribution45 total trials
Early Phase 1First-in-human
1(2.2%)
Phase 1Safety & dosage
20(44.4%)
Phase 2Efficacy & side effects
21(46.7%)
Phase 3Large-scale testing
3(6.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

36.4%

8 of 22 finished

Non-Completion Rate

63.6%

14 ended early

Currently Active

20

trials recruiting

Total Trials

45

all time

Status Distribution
Active(23)
Completed(8)
Terminated(14)

Detailed Status

Recruiting17
Terminated11
Completed8
Not yet recruiting3
Withdrawn3
Active, not recruiting3

Development Timeline

Analytics

Development Status

Total Trials
45
Active
20
Success Rate
42.1%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (2.2%)
Phase 120 (44.4%)
Phase 221 (46.7%)
Phase 33 (6.7%)

Trials by Status

not_yet_recruiting37%
recruiting1738%
terminated1124%
withdrawn37%
active_not_recruiting37%
completed818%

Recent Activity

Clinical Trials (45)

Showing 20 of 45 trialsScroll for more
NCT06414681Early Phase 1

Combination of Tagraxofusp With Pacritinib in Patients With Intermediate-1 or Higher Myelofibrosis, Who Have Had Prior Therapy With the Approved JAK Inhibitors or in Which Therapy With the Approved JAK Inhibitors is Not Appropriate, Contraindicated or Declined

Recruiting
NCT06303193Phase 1

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

Recruiting
NCT07226713Phase 2

Pacritinib in Participants With Metastatic Castrate-Resistant Prostate Cancer That Progressed on or After Prior Treatment With Androgen Receptor Signaling Inhibitors

Not Yet Recruiting
NCT07394153Phase 2

Pacritinib For Bone Marrow Fibrosis In Patients With Myelofibrosis Who Have Thrombocytopenia

Recruiting
NCT03165734Phase 3

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Active Not Recruiting
NCT06052618Phase 2

Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)

Recruiting
NCT06782373Phase 2

A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

Recruiting
NCT06516887Phase 1

Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma

Recruiting
NCT02891603Phase 1

A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression

Completed
NCT05531786Phase 1

Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Recruiting
NCT07447817Phase 2

Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias

Not Yet Recruiting
NCT07387354Phase 1

Pacritinib With Aza for Upfront Myelodysplastic Syndrome

Not Yet Recruiting
NCT04282187Phase 2

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT07033598Phase 2

Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia

Recruiting
NCT07148947Phase 2

Pacritinib With Standard of Care Azacitidine or Decitabine as a Bridge to Allogeneic Hematopoietic Stem Cell Transplant for Patients With Accelerated and Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT05980806Phase 2

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Recruiting
NCT04858256Phase 2

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

Recruiting
NCT06986174Phase 2

A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

Recruiting
NCT06675123Phase 1

Pacritinib in Combination With a BTK Inhibitor for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma

Recruiting
NCT04635059Phase 2

Pacritinib for Biochemical Relapse After Definitive Treatment for Prostate Cancer

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
45