Success Metrics

Clinical Success Rate
75.0%

Based on 6 completed trials

Completion Rate
75%(6/8)
Active Trials
8(42%)
Results Posted
83%(5 trials)
Terminated
2(11%)

Phase Distribution

Ph phase_1
5
26%
Ph phase_2
7
37%
Ph phase_3
4
21%
Ph phase_4
1
5%
Ph early_phase_1
1
5%

Phase Distribution

6

Early Stage

7

Mid Stage

5

Late Stage

Phase Distribution18 total trials
Early Phase 1First-in-human
1(5.6%)
Phase 1Safety & dosage
5(27.8%)
Phase 2Efficacy & side effects
7(38.9%)
Phase 3Large-scale testing
4(22.2%)
Phase 4Post-market surveillance
1(5.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.0%

6 of 8 finished

Non-Completion Rate

25.0%

2 ended early

Currently Active

8

trials recruiting

Total Trials

19

all time

Status Distribution
Active(10)
Completed(6)
Terminated(2)
Other(1)

Detailed Status

Recruiting8
Completed6
Not yet recruiting2
Terminated2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
8
Success Rate
75.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (5.6%)
Phase 15 (27.8%)
Phase 27 (38.9%)
Phase 34 (22.2%)
Phase 41 (5.6%)

Trials by Status

not_yet_recruiting211%
completed632%
unknown15%
recruiting842%
terminated211%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT07569081Phase 2

A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

Not Yet Recruiting
NCT04176198Phase 1

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

Recruiting
NCT06847867Phase 2

A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome

Recruiting
NCT06517875Phase 2

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

Recruiting
NCT06150157Phase 1

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

Recruiting
NCT07498205Phase 4

Comparing Momelotinib and Ruxolitinib in People With Untreated Myelofibrosis and Low Blood Cell Counts

Not Yet Recruiting
NCT07104799Phase 1

Momelotinib During and After HCT in Myelofibrosis

Recruiting
NCT07071155Early Phase 1

Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia

Recruiting
NCT05980806Phase 2

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Recruiting
NCT06235801Phase 1

A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia

Recruiting
NCT05582083

Managed Access Program for Momelotinib in Myelofibrosis

Unknown
NCT04173494Phase 3

A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)

Completed
NCT02101021Phase 3

Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Terminated
NCT02124746Phase 2

Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia

Completed
NCT02101268Phase 3

Efficacy of Momelotinib Versus Best Available Therapy in Anemic or Thrombocytopenic Subjects With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF

Completed
NCT01969838Phase 3

Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis

Completed
NCT01998828Phase 2

Safety and Efficacy of Momelotinib in Subjects With Polycythemia Vera or Essential Thrombocythemia

Terminated
NCT01423058Phase 1

Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis

Completed
NCT01236638Phase 2

Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Completed

All 19 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
19