Success Metrics

Clinical Success Rate
93.1%

Based on 27 completed trials

Completion Rate
93%(27/29)
Active Trials
8(18%)
Results Posted
78%(21 trials)
Terminated
2(5%)

Phase Distribution

Ph phase_4
8
18%
Ph phase_3
11
25%
Ph not_applicable
1
2%
Ph phase_2
16
36%
Ph phase_1
5
11%

Phase Distribution

5

Early Stage

16

Mid Stage

19

Late Stage

Phase Distribution41 total trials
Phase 1Safety & dosage
5(12.2%)
Phase 2Efficacy & side effects
16(39.0%)
Phase 3Large-scale testing
11(26.8%)
Phase 4Post-market surveillance
8(19.5%)
N/ANon-phased studies
1(2.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

93.1%

27 of 29 finished

Non-Completion Rate

6.9%

2 ended early

Currently Active

8

trials recruiting

Total Trials

44

all time

Status Distribution
Active(12)
Completed(27)
Terminated(2)
Other(3)

Detailed Status

Completed27
Recruiting7
Not yet recruiting4
unknown3
Terminated2
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
44
Active
8
Success Rate
93.1%
Most Advanced
Phase 4

Trials by Phase

Phase 15 (12.2%)
Phase 216 (39.0%)
Phase 311 (26.8%)
Phase 48 (19.5%)
N/A1 (2.4%)

Trials by Status

recruiting716%
unknown37%
active_not_recruiting12%
terminated25%
not_yet_recruiting49%
completed2761%

Recent Activity

8 active trials
Showing 5 of 44
recruitingphase_3

A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

NCT06615050
recruitingphase_2

A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)

NCT07280156
recruitingphase_2

An Open-Label Study of Effectiveness of Immunomodulatory Medications for Patients With Relapsing Polychondritis

NCT06941376
recruitingphase_2

Methotrexate for Severe Vulvar Lichen Sclerosus

NCT07352917
recruitingphase_2

MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial

NCT06541249
View all 44 trials

Clinical Trials (44)

Showing 20 of 44 trialsScroll for more
NCT06615050Phase 3

A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

Recruiting
NCT07280156Phase 2

A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)

Recruiting
NCT06941376Phase 2

An Open-Label Study of Effectiveness of Immunomodulatory Medications for Patients With Relapsing Polychondritis

Recruiting
NCT07352917Phase 2

Methotrexate for Severe Vulvar Lichen Sclerosus

Recruiting
NCT06541249Phase 2

MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial

Recruiting
NCT06590090Phase 2

Natrunix in Combination With Methotrexate for Rheumatoid Arthritis Treatment

Not Yet Recruiting
NCT04762498Phase 4

A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout (FORWARD OL)

Completed
NCT07190534

The Effectiveness of Hydroxychloroquine Versus Methotrexate in the Treatment of Frontal Fibrosing Alopecia in Routine Clinical Care: a Patient Preference Trial (FFA Trial)

Not Yet Recruiting
NCT07161336Phase 2

Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA

Recruiting
NCT06973811Phase 2

ZR-MTX for PIOL Phase II Trial

Not Yet Recruiting
NCT06965244Phase 3

Lenalidomide vs Methotrexate in Difficult-to-treat Cutaneous Lupus Erythematosus

Not Yet Recruiting
NCT06913907Phase 4

Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study)

Recruiting
NCT01451203Phase 3

Efficacy Confirmation Study of CDP870 in Early Rheumatoid Arthritis

Completed
NCT02867306Phase 1

A Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients With Rheumatoid Arthritis

Completed
NCT05036577Phase 1

A Dose-escalating Pilot Study of Orelabrutinib for Newly-diagnosed PCNSL

Active Not Recruiting
NCT04772313Phase 4

Pegloticase and Methotrexate Co-administered in Participants With Uncontrolled Gout Who Previously Failed Pegloticase Monotherapy

Completed
NCT03635957Phase 4

Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout

Completed
NCT00057954Phase 2

Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma

Terminated
NCT05135858Phase 1

Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System Lymphoma

Unknown
NCT03058900Not Applicable

Efficacy and Safety of Fecal Microbiota Transplantation in Peripheral Psoriatic Arthritis

Completed

Drug Details

Intervention Type
DRUG
Total Trials
44