Success Metrics

Clinical Success Rate
84.2%

Based on 16 completed trials

Completion Rate
84%(16/19)
Active Trials
2(8%)
Results Posted
56%(9 trials)
Terminated
3(12%)

Phase Distribution

Ph phase_2
15
60%
Ph phase_3
3
12%
Ph phase_1
6
24%

Phase Distribution

6

Early Stage

15

Mid Stage

3

Late Stage

Phase Distribution24 total trials
Phase 1Safety & dosage
6(25.0%)
Phase 2Efficacy & side effects
15(62.5%)
Phase 3Large-scale testing
3(12.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

76.2%

16 of 21 finished

Non-Completion Rate

23.8%

5 ended early

Currently Active

2

trials recruiting

Total Trials

25

all time

Status Distribution
Active(2)
Completed(16)
Terminated(5)
Other(2)

Detailed Status

Completed16
Terminated3
Withdrawn2
Active, not recruiting2
unknown2

Development Timeline

Analytics

Development Status

Total Trials
25
Active
2
Success Rate
84.2%
Most Advanced
Phase 3

Trials by Phase

Phase 16 (25.0%)
Phase 215 (62.5%)
Phase 33 (12.5%)

Trials by Status

withdrawn28%
terminated312%
active_not_recruiting28%
completed1664%
unknown28%

Recent Activity

Clinical Trials (25)

Showing 20 of 25 trialsScroll for more
NCT05229991Phase 3

Once Daily Dosing of Lonafarnib Co-administered With Ritonavir for Treatment of Chronic Hepatitis D Virus Infection

Completed
NCT06775041Phase 2

Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients With Hutchinson-Gilford Progeria Syndrome (HGPS)

Active Not Recruiting
NCT00102648Phase 1

Lonafarnib and Temozolomide in Treating Patients with Glioblastoma Multiforme That is Recurrent or Did Not Respond to Previous Treatment with Temozolomide

Active Not Recruiting
NCT02527707Phase 2

Titrating-Dose of Lonafarnib in Combination With Ritonavir

Completed
NCT03719313Phase 3

Study of the Efficacy and Safety of Lonafarnib / Ritonavir With and Without Pegylated Interferon -Alfa-2a

Completed
NCT02430194Phase 2

Lonafarnib Boosted With Ritonavir With and Without Peginterferon Alfa-2a (PEG IFN-a) in HDV (LOWR-2)

Completed
NCT02430181Phase 2

Lonafarnib With and Without Ritonavir in HDV (LOWR-1)

Completed
NCT03600714Phase 2

Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon

Completed
NCT03895528

Lonafarnib for Patients With Hutchinson-Gilford Progeria Syndrome or Progeroid Laminopathy

Unknown
NCT02968641Phase 2

A Study of Lonafarnib With or Without Ritonavir in Patients With HDV

Withdrawn
NCT00020774Phase 2

SCH 66336 With or Without Gemcitabine Followed by Surgery Compared With Surgery Alone in Treating Patients With Primary Liver Cancer

Withdrawn
NCT00425607Phase 2

Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria

Completed
NCT00879034Phase 2

A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria

Completed
NCT02511431Phase 2

Treatment of Chronic Delta Hepatitis With Lonafarnib and Ritonavir

Completed
NCT01495585Phase 2

Lonafarnib for Chronic Hepatitis D

Completed
NCT00773474Phase 2

Lonafarnib in Metastatic Breast Cancer

Terminated
NCT00109538Phase 3

Study of Lonafarnib Versus Placebo in Subjects With Either Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) (Study P02978AM3)(TERMINATED)

Terminated
NCT00081510Phase 2

Anastrozole Plus Lonafarnib (SCH 66336) or Plus Placebo for the Treatment of Advanced Breast Cancer (P03480)

Completed
NCT00083096Phase 1

Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas

Unknown
NCT00003956Phase 1

Combination Chemotherapy in Treating Patients With Advanced Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
25