Success Metrics

Clinical Success Rate
85.0%

Based on 17 completed trials

Completion Rate
85%(17/20)
Active Trials
0(0%)
Results Posted
65%(11 trials)
Terminated
3(13%)

Phase Distribution

Ph not_applicable
2
9%
Ph phase_1
14
61%
Ph phase_2
6
26%
Ph early_phase_1
1
4%

Phase Distribution

15

Early Stage

6

Mid Stage

0

Late Stage

Phase Distribution23 total trials
Early Phase 1First-in-human
1(4.3%)
Phase 1Safety & dosage
14(60.9%)
Phase 2Efficacy & side effects
6(26.1%)
N/ANon-phased studies
2(8.7%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

73.9%

17 of 23 finished

Non-Completion Rate

26.1%

6 ended early

Currently Active

0

trials recruiting

Total Trials

23

all time

Status Distribution
Completed(17)
Terminated(6)

Detailed Status

Completed17
Terminated3
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
23
Active
0
Success Rate
85.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (4.3%)
Phase 114 (60.9%)
Phase 26 (26.1%)
N/A2 (8.7%)

Trials by Status

terminated313%
completed1774%
withdrawn313%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT02195973Phase 1

Phase IB Trial of LDE225 and Paclitaxel in Recurrent Ovarian Cancer

Completed
NCT02027376Phase 1

Study of LDE225 (Sonidegib) in Combination With Docetaxel in Triple Negative (TN) Advanced Breast Cancer (ABC) Patients

Completed
NCT01769768Phase 1

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Completed
NCT01764776Phase 1

Effect of Hepatic Impairment on LDE225..

Completed
NCT01208831Phase 1

An East Asian Study of LDE225

Completed
NCT00880308Phase 1

Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors

Completed
NCT01576666Phase 1

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Completed
NCT01787552Phase 1

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Completed
NCT01954355Phase 1

LDE225 and Paclitaxel in Solid Tumors

Completed
NCT01327053Phase 2

A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma

Completed
NCT02182622Phase 1

LDE225 + Docetaxel/Prednisone for Adv/Met Castrate Resistant Prostate Cancer w/ Disease Progression After Docetaxel

Withdrawn
NCT02111187Phase 1

A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer

Completed
NCT02151864Phase 1

LDE225 in Patients With Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis

Completed
NCT02086513Phase 1

Phase I Trial of LDE225 for Steroid-refractory Chronic GVHD After Allogeneic HSCT

Terminated
NCT01708174Phase 2

A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB)

Completed
NCT01125800Phase 1

A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB

Completed
NCT02254551Phase 2

Safety/Efficacy Study of LDE225 (Sonidegib) Plus Bortezomib in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma

Terminated
NCT01529450Not Applicable

Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors

Completed
NCT01826214Phase 2

Study of Efficacy and Safety of LDE225 in Adult Patients With Relapsed/Refractory Acute Leukemia

Completed
NCT01911416Not Applicable

A Biomarker Study to Identify Predictive Signatures of Response to LDE225 (Hedgehog Inhibitor) In Patients With Resectable Pancreatic Cancer

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
23