Success Metrics

Clinical Success Rate
94.3%

Based on 33 completed trials

Completion Rate
94%(33/35)
Active Trials
0(0%)
Results Posted
97%(32 trials)
Terminated
2(5%)

Phase Distribution

Ph phase_4
5
14%
Ph phase_3
14
38%
Ph phase_1
2
5%
Ph phase_2
15
41%

Phase Distribution

2

Early Stage

15

Mid Stage

19

Late Stage

Phase Distribution36 total trials
Phase 1Safety & dosage
2(5.6%)
Phase 2Efficacy & side effects
15(41.7%)
Phase 3Large-scale testing
14(38.9%)
Phase 4Post-market surveillance
5(13.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

91.7%

33 of 36 finished

Non-Completion Rate

8.3%

3 ended early

Currently Active

0

trials recruiting

Total Trials

37

all time

Status Distribution
Completed(33)
Terminated(3)
Other(1)

Detailed Status

Completed33
Terminated2
Withdrawn1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
37
Active
0
Success Rate
94.3%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (5.6%)
Phase 215 (41.7%)
Phase 314 (38.9%)
Phase 45 (13.9%)

Trials by Status

terminated25%
withdrawn13%
completed3389%
unknown13%

Recent Activity

Clinical Trials (37)

Showing 20 of 37 trialsScroll for more
NCT03872778Phase 1

[177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-neoB Lesion Uptake

Completed
NCT03738878Phase 4

Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1

Terminated
NCT04164732Phase 2

Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy

Completed
NCT02884206Phase 3

Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction

Completed
NCT03917459Phase 3

COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure

Completed
NCT02468232Phase 3

Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction

Completed
NCT02678312Phase 2

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure

Completed
NCT02816736Phase 4

EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)

Completed
NCT03909295Phase 3

An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan.

Terminated
NCT02768298Phase 4

Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.

Completed
NCT02661217Phase 4

Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event

Completed
NCT02389933

Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)

Unknown
NCT00913653Phase 2

Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart Failure

Completed
NCT01920711Phase 3

Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction

Completed
NCT02226120Phase 3

Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

Completed
NCT02687932Phase 4

Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation

Completed
NCT01785472Phase 3

Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Asian Patients With Essential Hypertension

Completed
NCT01692301Phase 2

Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension

Completed
NCT01193101Phase 2

Efficacy and Safety of LCZ696 Compared to Placebo in Patients With Essential Hypertension

Completed
NCT01281306Phase 2

An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension

Completed

Drug Details

Intervention Type
DRUG
Total Trials
37