Success Metrics

Clinical Success Rate
80.0%

Based on 4 completed trials

Completion Rate
80%(4/5)
Active Trials
10(53%)
Results Posted
75%(3 trials)
Terminated
1(5%)

Phase Distribution

Ph not_applicable
2
11%
Ph phase_1
1
5%
Ph phase_2
4
21%
Ph phase_3
8
42%

Phase Distribution

1

Early Stage

4

Mid Stage

8

Late Stage

Phase Distribution15 total trials
Phase 1Safety & dosage
1(6.7%)
Phase 2Efficacy & side effects
4(26.7%)
Phase 3Large-scale testing
8(53.3%)
N/ANon-phased studies
2(13.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

80.0%

4 of 5 finished

Non-Completion Rate

20.0%

1 ended early

Currently Active

10

trials recruiting

Total Trials

19

all time

Status Distribution
Active(13)
Completed(4)
Terminated(1)
Other(1)

Detailed Status

Recruiting7
Completed4
Not yet recruiting3
Active, not recruiting3
Terminated1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
10
Success Rate
80.0%
Most Advanced
Phase 3

Trials by Phase

Phase 11 (6.7%)
Phase 24 (26.7%)
Phase 38 (53.3%)
N/A2 (13.3%)

Trials by Status

not_yet_recruiting316%
active_not_recruiting316%
completed421%
terminated15%
unknown15%
recruiting737%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT04889430Phase 3

Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy

Completed
NCT06517758Phase 3

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

Recruiting
NCT05755386Phase 3

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

Recruiting
NCT05935215Phase 3

Efficacy and Safety of Switching From Anti-C5 Antibody Treatment to Iptacopan Treatment in Study Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Recruiting
NCT04817618Phase 3

Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

Recruiting
NCT06797518Phase 2

Study to Evaluate the Impact of Iptacopan on Top of SOC on Biopsy Changes in Kidneys of Adult Patients With IgAN

Recruiting
NCT06388941Phase 2

Iptacopan in Patients With ANCA Associated Vasculitis

Active Not Recruiting
NCT04747613Phase 3

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

Active Not Recruiting
NCT06994845Phase 3

Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN

Recruiting
NCT07347990Not Applicable

Safety and Efficacy of Iptacopan in Patients With High-Risk Transplantation-Associated Thrombotic Microangiopathy

Not Yet Recruiting
NCT05630001Phase 3

Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan.

Completed
NCT07331259

CHART-C3G/CLNP023B12011

Not Yet Recruiting
NCT05222412

Managed Access Programs for LNP023, Iptacopan

Unknown
NCT05086744Phase 2

Basket Study to Assess Efficacy, Safety and PK of Iptacopan (LNP023) in Autoimmune Benign Hematological Disorders

Terminated
NCT06952426

A Mobile App-Based Study to Evaluate Disease Burden and Treatment Patterns in Immunoglobulin A Nephropathy (IgAN) in the US

Recruiting
NCT06903234

Post-authorization Safety Study of Iptacopan in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Using Data From the IPIG PNH Registry

Active Not Recruiting
NCT06847607Not Applicable

A Multicenter Prospective Study of Iptacopan in the Treatment of Refractory/Relapsed Autoimmune Hemolytic Anemia (AIHA)

Not Yet Recruiting
NCT03439839Phase 2

Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Completed
NCT05078580Phase 1

Pharmacokinetic (PK) and Safety Study of Iptacopan (LNP023) in Participants With Mild, Moderate, and Severe Hepatic Impairment Compared to Matched Control Healthy Participants With Normal Hepatic Function.

Completed

All 19 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
19