Success Metrics

Clinical Success Rate
58.8%

Based on 10 completed trials

Completion Rate
59%(10/17)
Active Trials
1(6%)
Results Posted
100%(10 trials)
Terminated
7(39%)

Phase Distribution

Ph phase_3
7
39%
Ph phase_1
7
39%
Ph phase_2
4
22%

Phase Distribution

7

Early Stage

4

Mid Stage

7

Late Stage

Phase Distribution18 total trials
Phase 1Safety & dosage
7(38.9%)
Phase 2Efficacy & side effects
4(22.2%)
Phase 3Large-scale testing
7(38.9%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

58.8%

10 of 17 finished

Non-Completion Rate

41.2%

7 ended early

Currently Active

1

trials recruiting

Total Trials

18

all time

Status Distribution
Active(1)
Completed(10)
Terminated(7)

Detailed Status

Completed10
Terminated7
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
1
Success Rate
58.8%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (38.9%)
Phase 24 (22.2%)
Phase 37 (38.9%)

Trials by Status

terminated739%
active_not_recruiting16%
completed1056%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT01760005Phase 2

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Active Not Recruiting
NCT05256134Phase 3

A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD)

Terminated
NCT06424236Phase 2

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation

Terminated
NCT04374253Phase 3

A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)

Terminated
NCT04592341Phase 2

A Study to Evaluate the Pharmacodynamic (PD) Effects of Once Weekly Administration of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

Terminated
NCT03444870Phase 3

Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

Terminated
NCT04339413Phase 3

A Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants With Alzheimer's Disease (AD)

Terminated
NCT03443973Phase 3

Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

Terminated
NCT02051608Phase 3

A Study of Gantenerumab in Participants With Mild Alzheimer Disease

Completed
NCT04623242Phase 2

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.

Completed
NCT01224106Phase 3

A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease

Completed
NCT02882009Phase 1

A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants

Completed
NCT02711423Phase 1

A Single-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Gantenerumab Following Subcutaneous (SC) Administration in Healthy Volunteers

Completed
NCT03236844Phase 1

Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants

Completed
NCT00531804Phase 1

A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease.

Completed
NCT01636531Phase 1

A Study of A High Concentration Liquid Formulation Versus A Lyophilized Formulation of Gantenerumab in Healthy Volunteers

Completed
NCT02133937Phase 1

A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers

Completed
NCT01656525Phase 1

A Multiple-dose Study of Gantenerumab in Japanese Alzheimer&Apos;s Disease Patients

Completed

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18