Defibrotide
Defibrotide is a pharmaceutical drug with 21 clinical trials. Currently 3 active trials ongoing. Historical success rate of 92.3%.
Success Metrics
Based on 12 completed trials
Phase Distribution
Phase Distribution
2
Early Stage
13
Mid Stage
4
Late Stage
Highest Phase Reached
Phase 4Trial Status & Enrollment
85.7%
12 of 14 finished
14.3%
2 ended early
3
trials recruiting
21
all time
Detailed Status
Development Timeline
Analytics
Development Status
Trials by Phase
Trials by Status
Recent Activity
Defibrotide Dose-escalation for SOS Post-HSCT
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma
Defibrotide for the Treatment of Severe COVID-19
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome
Clinical Trials (21)
Defibrotide Dose-escalation for SOS Post-HSCT
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma
Defibrotide for the Treatment of Severe COVID-19
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome
Defibrotide in Children With High Risk Kawasaki Disease
Defibrotide as Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome of Covid 19.
Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)
Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients
A Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated Neurotoxicity
Defibrotide TMA Prophylaxis Pilot Trial
An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD)
5-day Defibrotide Treatment for Hepatic SOS/VOD
Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
Compassionate Use of Defibrotide for Patients With Veno-occlusive Disease of the Liver
Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients
Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell Transplantation
Melphalan, Prednisone, Thalidomide and Defibrotide in Relapsed Multiple Myeloma Patients
Defibrotide Compassionate Use for Patients With Life Threatening Veno-Occlusive Disease of the Liver
Drug Details
- Intervention Type
- DRUG
- Total Trials
- 21