Success Metrics

Clinical Success Rate
92.3%

Based on 12 completed trials

Completion Rate
92%(12/13)
Active Trials
3(14%)
Results Posted
67%(8 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_4
1
5%
Ph phase_2
13
62%
Ph phase_3
3
14%
Ph phase_1
2
10%

Phase Distribution

2

Early Stage

13

Mid Stage

4

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
2(10.5%)
Phase 2Efficacy & side effects
13(68.4%)
Phase 3Large-scale testing
3(15.8%)
Phase 4Post-market surveillance
1(5.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

85.7%

12 of 14 finished

Non-Completion Rate

14.3%

2 ended early

Currently Active

3

trials recruiting

Total Trials

21

all time

Status Distribution
Active(3)
Completed(12)
Terminated(2)
Other(4)

Detailed Status

Completed12
unknown4
Recruiting3
Withdrawn1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
21
Active
3
Success Rate
92.3%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (10.5%)
Phase 213 (68.4%)
Phase 33 (15.8%)
Phase 41 (5.3%)

Trials by Status

unknown419%
withdrawn15%
terminated15%
completed1257%
recruiting314%

Recent Activity

Clinical Trials (21)

Showing 20 of 21 trialsScroll for more
NCT05987124Phase 2

Defibrotide Dose-escalation for SOS Post-HSCT

Recruiting
NCT02675959Phase 2

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

Recruiting
NCT06182410Phase 2

Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma

Withdrawn
NCT04652115Phase 2

Defibrotide for the Treatment of Severe COVID-19

Recruiting
NCT03805581Phase 2

Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

Completed
NCT04777422Phase 2

Defibrotide in Children With High Risk Kawasaki Disease

Unknown
NCT04348383Phase 2

Defibrotide as Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome of Covid 19.

Completed
NCT04530604Phase 1

Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)

Completed
NCT02851407Phase 3

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients

Completed
NCT03954106Phase 2

A Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated Neurotoxicity

Terminated
NCT03384693Phase 2

Defibrotide TMA Prophylaxis Pilot Trial

Completed
NCT03339297Phase 2

An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD)

Completed
NCT04313036Phase 2

5-day Defibrotide Treatment for Hepatic SOS/VOD

Unknown
NCT02876601Phase 4

Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide

Completed
NCT00628498Phase 3

Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study

Completed
NCT00143546

Compassionate Use of Defibrotide for Patients With Veno-occlusive Disease of the Liver

Unknown
NCT00358501Phase 3

Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients

Completed
NCT00003966Phase 2

Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell Transplantation

Completed
NCT00406978Phase 1

Melphalan, Prednisone, Thalidomide and Defibrotide in Relapsed Multiple Myeloma Patients

Completed
NCT00263978

Defibrotide Compassionate Use for Patients With Life Threatening Veno-Occlusive Disease of the Liver

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
21