Success Metrics

Clinical Success Rate
77.2%

Based on 376 completed trials

Completion Rate
77%(376/487)
Active Trials
130(18%)
Results Posted
64%(242 trials)
Terminated
111(15%)

Phase Distribution

Ph phase_3
81
11%
Ph phase_2
370
50%
Ph phase_4
3
0%
Ph phase_1
247
33%
Ph not_applicable
16
2%
Ph early_phase_1
6
1%

Phase Distribution

253

Early Stage

370

Mid Stage

84

Late Stage

Phase Distribution723 total trials
Early Phase 1First-in-human
6(0.8%)
Phase 1Safety & dosage
247(34.2%)
Phase 2Efficacy & side effects
370(51.2%)
Phase 3Large-scale testing
81(11.2%)
Phase 4Post-market surveillance
3(0.4%)
N/ANon-phased studies
16(2.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.9%

376 of 516 finished

Non-Completion Rate

27.1%

140 ended early

Currently Active

130

trials recruiting

Total Trials

738

all time

Status Distribution
Active(145)
Completed(376)
Terminated(140)
Other(77)

Detailed Status

Completed376
Terminated111
Recruiting81
unknown73
Active, not recruiting49
Withdrawn29

Development Timeline

Analytics

Development Status

Total Trials
738
Active
130
Success Rate
77.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 16 (0.8%)
Phase 1247 (34.2%)
Phase 2370 (51.2%)
Phase 381 (11.2%)
Phase 43 (0.4%)
N/A16 (2.2%)

Trials by Status

terminated11115%
enrolling_by_invitation10%
unknown7310%
withdrawn294%
not_yet_recruiting142%
active_not_recruiting497%
completed37651%
recruiting8111%
suspended41%

Recent Activity

Clinical Trials (738)

Showing 20 of 738 trialsScroll for more
NCT06589804Phase 3

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Recruiting
NCT05217446Phase 2

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer

Active Not Recruiting
NCT05355701Phase 1

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Recruiting
NCT06750094Phase 3

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

Recruiting
NCT06662786Phase 3

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

Recruiting
NCT06102902Phase 1

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

Suspended
NCT01810913Phase 2

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Suspended
NCT07042295Phase 2

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

Recruiting
NCT04892173Phase 3

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

Recruiting
NCT05382559Phase 1

A Study of ASP3082 in Adults With Advanced Solid Tumors

Recruiting
NCT05063552Phase 2

Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

Active Not Recruiting
NCT05067283Phase 1

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Recruiting
NCT07672483Phase 1

IL-12 Genetically Engineered Myeloid Cells in Participants With Relapsed, Refractory Solid Tumors

Not Yet Recruiting
NCT06239220Phase 2

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

Recruiting
NCT07252739Phase 2

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Recruiting
NCT04290546Phase 1

CIML NK Cell in Head & Neck Cancer

Completed
NCT06448026Phase 2

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma

Recruiting
NCT06764771Phase 1

A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors

Recruiting
NCT01468896Phase 1

Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery

Active Not Recruiting
NCT03785249Phase 1

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Active Not Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
738