Success Metrics

Clinical Success Rate
78.0%

Based on 372 completed trials

Completion Rate
78%(372/477)
Active Trials
137(19%)
Results Posted
64%(237 trials)
Terminated
105(14%)

Phase Distribution

Ph phase_2
366
50%
Ph early_phase_1
6
1%
Ph phase_1
245
34%
Ph phase_3
80
11%
Ph phase_4
3
0%
Ph not_applicable
16
2%

Phase Distribution

251

Early Stage

366

Mid Stage

83

Late Stage

Phase Distribution716 total trials
Early Phase 1First-in-human
6(0.8%)
Phase 1Safety & dosage
245(34.2%)
Phase 2Efficacy & side effects
366(51.1%)
Phase 3Large-scale testing
80(11.2%)
Phase 4Post-market surveillance
3(0.4%)
N/ANon-phased studies
16(2.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

73.5%

372 of 506 finished

Non-Completion Rate

26.5%

134 ended early

Currently Active

137

trials recruiting

Total Trials

731

all time

Status Distribution
Active(151)
Completed(372)
Terminated(134)
Other(74)

Detailed Status

Completed372
Terminated105
Recruiting87
unknown74
Active, not recruiting50
Withdrawn29

Development Timeline

Analytics

Development Status

Total Trials
731
Active
137
Success Rate
78.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 16 (0.8%)
Phase 1245 (34.2%)
Phase 2366 (51.1%)
Phase 380 (11.2%)
Phase 43 (0.4%)
N/A16 (2.2%)

Trials by Status

withdrawn294%
completed37251%
not_yet_recruiting142%
recruiting8712%
active_not_recruiting507%
terminated10514%
unknown7410%

Recent Activity

Clinical Trials (731)

Showing 20 of 731 trialsScroll for more
NCT06102902Phase 1

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

Recruiting
NCT06835569Phase 1

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

Recruiting
NCT06589804Phase 3

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Recruiting
NCT05249426Phase 1

A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer

Active Not Recruiting
NCT02270814Phase 2

Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients With Incurable Head and Neck Squamous Cell Carcinoma

Active Not Recruiting
NCT05863195Phase 3

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Recruiting
NCT05355701Phase 1

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Recruiting
NCT01810913Phase 2

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Recruiting
NCT06179160Phase 1

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Recruiting
NCT05063552Phase 2

Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

Active Not Recruiting
NCT07209111Phase 2

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

Recruiting
NCT05067283Phase 1

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Recruiting
NCT07441681Phase 3

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

Not Yet Recruiting
NCT07042295Phase 2

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

Recruiting
NCT07252739Phase 2

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Recruiting
NCT05004350Phase 2

A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

Completed
NCT07535112Phase 1

A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

Recruiting
NCT01468896Phase 1

Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery

Active Not Recruiting
NCT06806852Phase 1

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

Recruiting
NCT06997497Phase 3

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
731