Success Metrics

Clinical Success Rate
61.6%

Based on 154 completed trials

Completion Rate
62%(154/250)
Active Trials
143(31%)
Results Posted
92%(142 trials)
Terminated
96(21%)

Phase Distribution

Ph early_phase_1
2
0%
Ph not_applicable
13
3%
Ph phase_3
46
10%
Ph phase_4
6
1%
Ph phase_2
176
38%
Ph phase_1
209
46%

Phase Distribution

211

Early Stage

176

Mid Stage

52

Late Stage

Phase Distribution452 total trials
Early Phase 1First-in-human
2(0.4%)
Phase 1Safety & dosage
209(46.2%)
Phase 2Efficacy & side effects
176(38.9%)
Phase 3Large-scale testing
46(10.2%)
Phase 4Post-market surveillance
6(1.3%)
N/ANon-phased studies
13(2.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

57.5%

154 of 268 finished

Non-Completion Rate

42.5%

114 ended early

Currently Active

143

trials recruiting

Total Trials

458

all time

Status Distribution
Active(162)
Completed(154)
Terminated(114)
Other(28)

Detailed Status

Completed154
Terminated96
Recruiting95
Active, not recruiting48
unknown23
Withdrawn18

Development Timeline

Analytics

Development Status

Total Trials
458
Active
143
Success Rate
61.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (0.4%)
Phase 1209 (46.2%)
Phase 2176 (38.9%)
Phase 346 (10.2%)
Phase 46 (1.3%)
N/A13 (2.9%)

Trials by Status

active_not_recruiting4810%
withdrawn184%
unknown235%
suspended51%
terminated9621%
completed15434%
enrolling_by_invitation10%
recruiting9521%
not_yet_recruiting184%

Recent Activity

Clinical Trials (458)

Showing 20 of 458 trialsScroll for more
NCT07581002Phase 2

A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)

Recruiting
NCT07304011Phase 2

Olutasidenib With Azacitidine Followed by Olutasidenib Maintenance for the Treatment of IDH1-mutated Acute Myeloid Leukemia in Patients With Prior Treatment With Venetoclax Plus a Hypomethylating Agent

Recruiting
NCT07458542

Effectiveness and Safety of ONUREG (Oral Azacitidine) in Chinese Patients With Acute Myeloid Leukemia

Completed
NCT05554419Phase 2

Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial)

Not Yet Recruiting
NCT06419634Phase 1

Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Terminated
NCT06763341Phase 1

A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Recruiting
NCT03564873Phase 1

Omacetaxine + Azacitidine in Untreated Patients With High Grade MDS

Active Not Recruiting
NCT07478991Phase 3

Azacytidine, Venetoclax Plus Minus Quizartinib for First Line Older/Unfit AML Patients (VENP-A-QUI)

Recruiting
NCT05554393Phase 2

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Recruiting
NCT06548230Phase 1

A Phase 1B/2A Trial of NADUNOLIMAB in Combination With Azacitidine (With/Without Venetoclax) in Patients With Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)

Recruiting
NCT05564390Phase 2

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Recruiting
NCT03874052Phase 1

Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT06014489Phase 2

A Trial to Assess Cobicistat Boosted Venetoclax in Combination With Azacitidine in Adult Patients With Newly Diagnosed AML

Recruiting
NCT04266795Phase 2

A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy

Completed
NCT06317649Phase 2

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

Recruiting
NCT05201066Phase 2

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.

Active Not Recruiting
NCT05554406Phase 2

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

Recruiting
NCT03588078Phase 1

Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine

Completed
NCT04734990Phase 1

Seclidemstat and Azacitidine for the Treatment of Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Active Not Recruiting
NCT07828535Phase 1

Liposomal Mitoxantrone Plus Azacitidine and Venetoclax in Newly Diagnosed Elderly or Unfit AML

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
458