Success Metrics

Clinical Success Rate
86.6%

Based on 97 completed trials

Completion Rate
87%(97/112)
Active Trials
15(9%)
Results Posted
62%(60 trials)
Terminated
15(9%)

Phase Distribution

Ph phase_2
49
30%
Ph not_applicable
8
5%
Ph phase_3
38
23%
Ph early_phase_1
1
1%
Ph phase_4
34
21%
Ph phase_1
17
10%

Phase Distribution

18

Early Stage

49

Mid Stage

72

Late Stage

Phase Distribution147 total trials
Early Phase 1First-in-human
1(0.7%)
Phase 1Safety & dosage
17(11.6%)
Phase 2Efficacy & side effects
49(33.3%)
Phase 3Large-scale testing
38(25.9%)
Phase 4Post-market surveillance
34(23.1%)
N/ANon-phased studies
8(5.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.9%

97 of 123 finished

Non-Completion Rate

21.1%

26 ended early

Currently Active

15

trials recruiting

Total Trials

163

all time

Status Distribution
Active(16)
Completed(97)
Terminated(26)
Other(24)

Detailed Status

Completed97
unknown24
Terminated15
Withdrawn11
Active, not recruiting8
Recruiting7

Development Timeline

Analytics

Development Status

Total Trials
163
Active
15
Success Rate
86.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.7%)
Phase 117 (11.6%)
Phase 249 (33.3%)
Phase 338 (25.9%)
Phase 434 (23.1%)
N/A8 (5.4%)

Trials by Status

completed9760%
terminated159%
not_yet_recruiting11%
recruiting74%
unknown2415%
withdrawn117%
active_not_recruiting85%

Recent Activity

Clinical Trials (163)

Showing 20 of 163 trialsScroll for more
NCT07440225Phase 2

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Recruiting
NCT07496567Phase 2

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

Recruiting
NCT07482176Phase 3

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

Recruiting
NCT06556368Phase 3

A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK

Active Not Recruiting
NCT06850922Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular Edema

Active Not Recruiting
NCT07317934Phase 3

Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (STELLAR)

Recruiting
NCT07390253

Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular Degeneration

Active Not Recruiting
NCT04932980Not Applicable

Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD

Active Not Recruiting
NCT06856577Phase 3

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

Recruiting
NCT04567550Phase 2

RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)

Active Not Recruiting
NCT03832179Phase 4

Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification

Completed
NCT04270747Phase 3

A Study to Understand Effectiveness and Safety of ABP 938 Compared to Aflibercept (Eylea®) in Patients Suffering With Neovascular Age-related Macular Degeneration [Neovascular (Wet) AMD]

Completed
NCT02257502Phase 2

Study Evaluating the Efficacy of Aflibercept for the Treatment of NVCI in Young Patients

Completed
NCT04429503Phase 2

Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease

Completed
NCT02556229Phase 2

Study Evaluating the Efficacy of Aflibercept for the Treatment of Inflammatory CNV in Young Patients (ALINEA).

Completed
NCT06011798Phase 2

Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)

Completed
NCT05891548Phase 2

Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration

Completed
NCT03823287Phase 3

A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)

Completed
NCT03823300Phase 3

A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)

Completed
NCT03622580Phase 3

A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
163