Key Insights

Highlights

Success Rate

71% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 39/100

Termination Rate

10.5%

2 terminated out of 19 trials

Success Rate

71.4%

-15.1% vs benchmark

Late-Stage Pipeline

26%

5 trials in Phase 3/4

Results Transparency

60%

3 of 5 completed with results

Key Signals

3 with results71% success

Data Visualizations

Phase Distribution

10Total
Not Applicable (3)
Early P 1 (1)
P 1 (1)
P 3 (2)
P 4 (3)

Trial Status

Recruiting7
Completed5
Active Not Recruiting3
Terminated2
Unknown1
Not Yet Recruiting1

Trial Success Rate

71.4%

Benchmark: 86.5%

Based on 5 completed trials

Clinical Trials (19)

Showing 19 of 19 trials
NCT07298044Phase 4RecruitingPrimary

A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis

NCT06194825Phase 3Active Not RecruitingPrimary

EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy

NCT07448623Phase 1RecruitingPrimary

A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT Imaging in People With ATTR Amyloidosis.

NCT06183931Phase 3Active Not RecruitingPrimary

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM

NCT07170306Not Yet Recruiting

Cardiac Amyloidosis in Patients With Aortic Stenosis

NCT06257485Active Not Recruiting

Bronx Transthyretin Amyloid Cardiomyopathy Database

NCT06321523CompletedPrimary

A Study to Learn About the Study Medicine Called Tafamidis 61mg in People Diagnosed With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

NCT06086353CompletedPrimary

A Study to Learn About Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in India

NCT06291805Recruiting

Phenotyping and Characterization of wtATTR-CM (TRACE 1)

NCT05259072Terminated

carDIo-ttranSSfOrm nucLEar Imaging Study

NCT04814186Phase 4CompletedPrimary

A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

NCT06539169Recruiting

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

NCT04899180Early Phase 1Completed

Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis

NCT06101108RecruitingPrimary

Early Diagnosis of Age-Linked CArdiac TransThyRetin Amyloidosis by Selective Screening in Spinal Stenosis Surgery

NCT05233163Phase 4CompletedPrimary

SGLT2 Inhibitors in Transthyretin Amyloid Cardiomyopathy

NCT04424914Not ApplicableTerminatedPrimary

Global Prevalence of ATTR-CM in Participants With HFpEF

NCT06372301Not ApplicableRecruitingPrimary

Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy

NCT06328075Recruiting

Artificial Intelligence to Assist the Echocardiographic Identification of Transthyretin Cardiac Amyloidosis

NCT05896904Not ApplicableUnknownPrimary

Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction

Showing all 19 trials

Research Network

Activity Timeline