Key Insights

Highlights

Success Rate

79% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

14.3%

8 terminated out of 56 trials

Success Rate

79.5%

-7.1% vs benchmark

Late-Stage Pipeline

5%

3 trials in Phase 3/4

Results Transparency

13%

4 of 31 completed with results

Key Signals

4 with results79% success

Data Visualizations

Phase Distribution

37Total
Not Applicable (26)
Early P 1 (1)
P 1 (6)
P 2 (1)
P 3 (3)

Trial Status

Completed31
Terminated8
Recruiting7
Unknown3
Withdrawn3
Active Not Recruiting3

Trial Success Rate

79.5%

Benchmark: 86.6%

Based on 31 completed trials

Clinical Trials (56)

Showing 20 of 20 trials
NCT06061614Early Phase 1Active Not RecruitingPrimary

Safety and Efficacy Study of NGGT002 in PKU Adult Subjects

NCT03655223Active Not Recruiting

Early Check: Expanded Screening in Newborns

NCT03856203CompletedPrimary

Nutrition Status of Adults With PKU Before and During Treatment With Pegvaliase

NCT04433728TerminatedPrimary

Life With Phenylketonuria. Adult Neurological Outcome of PCU Screened Patients From 1971 to 2002.

NCT05051657Not ApplicableCompletedPrimary

Evaluation of the Express Plus Range

NCT04679467Not ApplicableCompletedPrimary

Evaluation of PKU Sphere in Italy

NCT05827536Not ApplicableTerminatedPrimary

Open-label, Randomized, 2-way Crossover, Monocentric, Controlled Study to Evaluate the Effect on Daily PHE Fluctuation of PKU GOLIKE Versus SoC in Patients With PKU.

NCT05487378Not ApplicableCompletedPrimary

Evaluation of Phe Fluctuation in PKU Pts Treated With PKU GOLIKE Versus Standard Amino Acid Protein Substitute.

NCT04404530RecruitingPrimary

Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)

NCT05356377CompletedPrimary

Preliminary Study of Brain Effects of Palynziq-Related Changes in Phenylalanine in Individuals With PKU

NCT06560736Not ApplicableRecruitingPrimary

Development of Novel Psychological Assessment Tools and Anxiety Intervention for Phenylketonuria

NCT06332807Phase 1RecruitingPrimary

AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)

NCT04898829Not ApplicableCompletedPrimary

Evaluation of PKU Explore France

NCT05998109CompletedPrimary

PheCheck Feasibility Study

NCT04076176Not ApplicableCompletedPrimary

The Effects of CGMP in Children and Adults With PKU

NCT05128149RecruitingPrimary

Metabolic Control and Patient Well-being in Phenylketonuria: do Guidelines Make a Difference?

NCT06337864Not ApplicableRecruiting

Effect of Large Neutral Amino Acids in Adults With Classical Phenylketonuria

NCT05971563Not ApplicableCompletedPrimary

Amino Acid Kinetics of GMP-AA in Healthy Human Volunteers

NCT04272736Not ApplicableWithdrawnPrimary

PKU Low Calorie Drink Study

NCT06718842Not ApplicableRecruitingPrimary

Walking Program in Fatty Liver Children With Phenylketonuria

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