Key Insights

Highlights

Success Rate

73% trial completion

Published Results

32 trials with published results (29%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

16.4%

18 terminated out of 110 trials

Success Rate

72.7%

-13.8% vs benchmark

Late-Stage Pipeline

10%

11 trials in Phase 3/4

Results Transparency

67%

32 of 48 completed with results

Key Signals

32 with results73% success18 terminated

Data Visualizations

Phase Distribution

85Total
Not Applicable (12)
Early P 1 (1)
P 1 (24)
P 2 (37)
P 3 (10)
P 4 (1)

Trial Status

Completed48
Terminated18
Recruiting17
Active Not Recruiting11
Not Yet Recruiting7
Withdrawn5

Trial Success Rate

72.7%

Benchmark: 86.5%

Based on 48 completed trials

Clinical Trials (110)

Showing 20 of 20 trials
NCT06018558Phase 1Active Not RecruitingPrimary

Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy

NCT07602127Early Phase 1Not Yet RecruitingPrimary

Safety and Efficacy Study of Novel Gene Therapy AGX-08 for Geographic Atrophy

NCT06381596Not ApplicableCompletedPrimary

Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration

NCT06769048Phase 2Active Not RecruitingPrimary

A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

NCT06779773RecruitingPrimary

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

NCT06164587Phase 1CompletedPrimary

Evaluation of Kamuvudine-8 in Subjects With Geographic Atrophy

NCT07705568Phase 2Not Yet RecruitingPrimary

An Open-label Safety, Tolerability and Exploratory Efficacy Clinical Trial of PST-611 in Geographic Atrophy

NCT05626114Phase 2RecruitingPrimary

A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

NCT07160179Phase 1RecruitingPrimary

Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT05961332Not ApplicableCompleted

COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Geographic Atrophy

NCT06635148Phase 2RecruitingPrimary

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

NCT06970665Phase 4Active Not RecruitingPrimary

A Study About the Safety of ASP3021 Eye Injections and if They Help People in Japan With Vision Loss From Age-related Macular Degeneration

NCT07215234Phase 1RecruitingPrimary

A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

NCT04339764Phase 1Recruiting

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT07594236Phase 1RecruitingPrimary

Phase 1 Study of C.001 in Retinal Degeneration

NCT06161584Active Not RecruitingPrimary

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT04676854Not ApplicableActive Not RecruitingPrimary

Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD

NCT07606365Phase 2Not Yet RecruitingPrimary

A Study in Adults With Geographic Atrophy

NCT05536297Phase 3CompletedPrimary

Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy

NCT05941273Not ApplicableWithdrawn

A Study of the SING IMT in an Israeli Cohort

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