Key Insights

Highlights

Success Rate

85% trial completion

Research Maturity

72 completed trials (22% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

4.0%

13 terminated out of 322 trials

Success Rate

84.7%

-1.8% vs benchmark

Late-Stage Pipeline

9%

30 trials in Phase 3/4

Results Transparency

14%

10 of 72 completed with results

Key Signals

10 with results85% success13 terminated

Data Visualizations

Phase Distribution

280Total
Not Applicable (32)
Early P 1 (2)
P 1 (56)
P 2 (160)
P 3 (28)
P 4 (2)

Trial Status

Unknown92
Recruiting83
Completed72
Not Yet Recruiting29
Active Not Recruiting23
Terminated13

Trial Success Rate

84.7%

Benchmark: 86.5%

Based on 72 completed trials

Clinical Trials (322)

Showing 20 of 20 trials
NCT05319730Phase 1RecruitingPrimary

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

NCT06971848Not ApplicableNot Yet Recruiting

Evaluation of Skin Tests in Biotherapy Allergies

NCT07284186Phase 1RecruitingPrimary

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

NCT06780111Phase 1RecruitingPrimary

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

NCT07629817Phase 3Not Yet RecruitingPrimary

Surgery vs. Radical Chemoradiotherapy for Esophageal SCC After Neoadjuvant Immunochemotherapy

NCT07623642Phase 2Not Yet Recruiting

A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.

NCT07217171Phase 1Recruiting

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

NCT07618910Phase 2Not Yet RecruitingPrimary

Retlirafusp Alfa Plus Chemotherapy as Neoadjuvant Therapy for Thoracic ESCC

NCT07452601Phase 2RecruitingPrimary

Time-of-Day of Immunotherapy Infusion in Neoadjuvant Immunochemotherapy for Thoracic ESCC

NCT06010303Phase 2Completed

A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma

NCT07605663Active Not RecruitingPrimary

an AI-Driven Four-Tier Invasion Depth Classification for Early Esophageal Cancer

NCT07109726Phase 1Recruiting

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

NCT04550260Phase 3Active Not RecruitingPrimary

Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC

NCT07403136Phase 2RecruitingPrimary

Vebrekotuzumab ± Anti-PD-1 in Pretreated Advanced ESCC

NCT04389632Phase 1Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT07554521Phase 2Recruiting

A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States

NCT05799274Phase 1Recruiting

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

NCT07554456Phase 2Not Yet RecruitingPrimary

A Study of BL-B01D1 in Combination With Tislelizumab ±5-Fluorouracil Versus Platinum-Based Chemotherapy Plus Tislelizumab as First-line Treatment in Patients With Unresectable, Locally Advanced Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus02)

NCT07244978Phase 2Not Yet RecruitingPrimary

Neoadjuvant Ivonescimab(AK112) Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma

NCT06401447Not ApplicableActive Not RecruitingPrimary

TPF Concurrent Chemo-radiotherapy Plus Immunotherapy for Local Advanced Esophageal Squamous Cell Carcinoma

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