Key Insights

Highlights

Success Rate

33% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

13.3%

2 terminated out of 15 trials

Success Rate

33.3%

-53.2% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

100%

1 of 1 completed with results

Key Signals

1 with results33% success

Data Visualizations

Phase Distribution

10Total
Not Applicable (1)
Early P 1 (1)
P 1 (2)
P 2 (6)

Trial Status

Recruiting7
Terminated2
Unknown2
Active Not Recruiting1
Completed1
Not Yet Recruiting1

Trial Success Rate

33.3%

Benchmark: 86.5%

Based on 1 completed trials

Clinical Trials (15)

Showing 15 of 15 trials
NCT01552434Phase 1Active Not Recruiting

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

NCT07440290Phase 2Not Yet Recruiting

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

NCT05093335Early Phase 1Recruiting

In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET

NCT03329274RecruitingPrimary

Registry for Patients With Erdheim-Chester Disease and Other Histiocytoses

NCT05768178Phase 2Recruiting

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

NCT04079179Phase 2Recruiting

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

NCT05915208Recruiting

Histiocytic Disorder Follow-up Study

NCT04198818Phase 1Terminated

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors

NCT06332183RecruitingPrimary

GWAS and EWAS in Patients With Erdheim-Chester Disease

NCT06317246Not ApplicableRecruitingPrimary

Subtypes and Prognostic Factors in Erdheim-Chester Disease

NCT05092815Phase 2Unknown

The Efficacy and Safety of HLX208 in Adult Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) With BRAF V600E Mutation

NCT03794297Phase 2WithdrawnPrimary

Dabrafenib and Trametinib in Treating Patients With Erdheim Chester Disease With BRAF V600 Mutations

NCT02608619CompletedPrimary

Uptake and Biodistribution of 18F-fluorocholine in Histiocytic Disorders by PET Imaging and Biopsy Measurement

NCT02089724UnknownPrimary

Long-term Outcome After Vemurafenib / BRAF Inhibitors Interruption in Erdheim-chester Disease

NCT01727206Phase 2TerminatedPrimary

Pilot Study of Tocilizumab in Patients With Erdheim-Chester Disease

Showing all 15 trials

Research Network

Activity Timeline