Key Insights

Highlights

Success Rate

91% trial completion (above average)

Published Results

12 trials with published results (21%)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 27/100

Termination Rate

5.4%

3 terminated out of 56 trials

Success Rate

90.6%

+4.1% vs benchmark

Late-Stage Pipeline

18%

10 trials in Phase 3/4

Results Transparency

41%

12 of 29 completed with results

Key Signals

12 with results91% success

Data Visualizations

Phase Distribution

48Total
Not Applicable (22)
Early P 1 (2)
P 1 (4)
P 2 (10)
P 3 (6)
P 4 (4)

Trial Status

Completed29
Recruiting11
Unknown10
Terminated3
Withdrawn2
Not Yet Recruiting1

Trial Success Rate

90.6%

Benchmark: 86.6%

Based on 29 completed trials

Clinical Trials (56)

Showing 20 of 20 trials
NCT07758010Not ApplicableNot Yet RecruitingPrimary

One-Day cTBS Over the Precuneus

NCT04469959Phase 2Completed

Dopaminergic Dysfunction in Late-Life Depression

NCT07284667Phase 2Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

NCT03851380Completed

Improving Brain Stimulation Through Imaging

NCT07053345Phase 4CompletedPrimary

A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression

NCT07716098Phase 3RecruitingPrimary

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

NCT02153502Phase 2CompletedPrimary

Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment

NCT06511908Phase 2Recruiting

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT02994433Phase 1Recruiting

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

NCT05570344Not ApplicableRecruitingPrimary

rTMS With and Without Text4Support for the Treatment of Resistant Depression.

NCT02942368Phase 1TerminatedPrimary

Adaptive tDCS for Treatment-Resistant MDD

NCT06854367Not ApplicableRecruiting

Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression

NCT04159012Not ApplicableWithdrawn

NESBID: Neuro-Stimulation of the Brain in Depression

NCT04956016Not ApplicableRecruitingPrimary

Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment

NCT06668571Phase 2RecruitingPrimary

Intravenous Ketamine for Treatment-Resistant Depression

NCT06431386Not ApplicableTerminatedPrimary

Behavioural Activation Therapy and Esketamine for Resistant Depression

NCT06650800Not ApplicableCompleted

Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression

NCT03829579UnknownPrimary

Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)

NCT03887624Early Phase 1CompletedPrimary

Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.

NCT02782104Phase 3CompletedPrimary

A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression

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