Depressive Disorder, Treatment-Resistant
56
11
11
29
Key Insights
Highlights
Success Rate
91% trial completion (above average)
Published Results
12 trials with published results (21%)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
5.4%
3 terminated out of 56 trials
90.6%
+4.1% vs benchmark
18%
10 trials in Phase 3/4
41%
12 of 29 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 29 completed trials
Clinical Trials (56)
One-Day cTBS Over the Precuneus
Dopaminergic Dysfunction in Late-Life Depression
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Improving Brain Stimulation Through Imaging
A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
rTMS With and Without Text4Support for the Treatment of Resistant Depression.
Adaptive tDCS for Treatment-Resistant MDD
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
NESBID: Neuro-Stimulation of the Brain in Depression
Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
Intravenous Ketamine for Treatment-Resistant Depression
Behavioural Activation Therapy and Esketamine for Resistant Depression
Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression
Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)
Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression