Key Insights

Highlights

Success Rate

77% trial completion

Published Results

20 trials with published results (16%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

11.2%

14 terminated out of 125 trials

Success Rate

77.4%

-9.1% vs benchmark

Late-Stage Pipeline

3%

4 trials in Phase 3/4

Results Transparency

42%

20 of 48 completed with results

Key Signals

20 with results77% success14 terminated

Data Visualizations

Phase Distribution

117Total
Not Applicable (5)
Early P 1 (3)
P 1 (72)
P 2 (33)
P 3 (4)

Trial Status

Completed48
Recruiting23
Unknown18
Terminated14
Withdrawn9
Active Not Recruiting7

Trial Success Rate

77.4%

Benchmark: 86.5%

Based on 48 completed trials

Clinical Trials (125)

Showing 20 of 20 trials
NCT05442515Phase 1Recruiting

CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies

NCT05365659Phase 1Recruiting

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

NCT06634589Phase 1Recruiting

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

NCT05024045Phase 1Completed

Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

NCT07101328Phase 1Recruiting

A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

NCT05653271Phase 1CompletedPrimary

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

NCT07652580Recruiting

Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

NCT05934838Phase 1Active Not Recruiting

A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

NCT05092451Phase 1RecruitingPrimary

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

NCT07616089Phase 1Not Yet RecruitingPrimary

Phase I Study of FXS0683 in the Treatment of Blood Tumors

NCT05615636Phase 2Recruiting

A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL

NCT07593482Phase 2Not Yet RecruitingPrimary

Bendamustine Versus Fludarabine/Cyclophosphamide for Lymphodepletion in Chimeric Antigen Receptor T-cell Immunotherapy (CAR-T): a Randomized Trial.

NCT07093086Phase 1WithdrawnPrimary

Clinical Study of Multi-targeted CAR-T Therapy in Patients With Relapsed/Refractory B-Cell Lymphoma

NCT05757700Phase 1Active Not RecruitingPrimary

Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Lymphoma

NCT07162181Phase 2Active Not Recruiting

Long-Term Safety of Pirtobrutinib in Participants With Previously Treated Types of Blood Cancers

NCT04491370Phase 1RecruitingPrimary

Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

NCT07520006Phase 1Not Yet RecruitingPrimary

Study of NX-5948 in Combination With Other Agents in Adults With B-cell Malignancies

NCT07516093Phase 3Not Yet RecruitingPrimary

Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL

NCT07474051Enrolling By InvitationPrimary

Long-Term Follow-Up of AvenCell Sponsored CAR-T Cell Clinical Trials

NCT07369492Phase 1RecruitingPrimary

Safety and Efficacy Study of BAFF-R CAR-T Cells in Adult Subjects With CD19-Negative Relapsed or Refractory B-Cell Lymphoma

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