Bioequivalence of Tofacitinib 10 mg Film-Coated Tablets in Healthy Subjects Under Fasting Conditions.

You may not qualify if:

• Known hypersensitivity/allergy reaction to the study drug substance or any of the excipients.
• Known severe hypersensitivity reaction to any other drug.
• Known rare hereditary problems of galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption.
• Any medical condition (e.g., gastrointestinal, renal or hepatic, including peptic ulcer, inflammatory bowel disease or pancreatitis) or surgical condition (e.g., cholecystectomy, gastrectomy) that may affect drug pharmacokinetics (absorption, distribution, metabolism or excretion) or subject’s safety.
• History of gastrointestinal perforation or diverticulitis.
• History of diabetes mellitus.
• Active or history of tuberculosis.
• Presence of an active infection, including localized infections.
• History of a serious or an opportunistic infection.
• History of recurrent infections.
• Resided or traveled in areas of endemic tuberculosis or endemic mycoses (i.e., within last 3 months prior to screening), or has underlying condition that may predispose to infection.
• History of thrombosis, including pulmonary embolism, deep vein thrombosis and arterial thrombosis or of risk factors for thromboembolic events (e.g., inherited hypercoagulable disorders and auto-immune disorders with hypercoagulable states).
• History of cardiovascular events, including myocardial infarction and stroke.
• History of any malignancies.
• Family history of sudden death before 40 years old.
• +29 more criteria