NCT07907718|Not Yet Recruiting
Cognitive-Motor Training for Gait Adaptability in Parkinson Disease
Cognitive-Motor Training on Cognitive Function and Gait Adaptability in People With Parkinson's Disease
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Cognitive-Motor Training on Cognitive Function and Gait Adaptability in People With Parkinson's Disease
Sponsor study identifier
interventional
50
1 country
1
Study Start
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands. Training that involves stopping or changing a movement may help people with Parkinson's disease respond to changing situations. These abilities may also support walking in challenging environments, such as stepping over obstacles. However, the effects of this type of training on cognitive function, walking performance, and brain activity remain unclear. Therefore, this study aims to compare the effects of cognitive-motor co-dependent training with conventional exercise training on these outcomes in people with Parkinson's disease.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 24, 2026
Actual (reported)October 30, 2026
Actual (reported)November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Gait speed
Gait speed during obstacle crossing was measured using the GAITRite system. Continuous obstacle-crossing walking performance was assessed using the GaitUp system.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Step length
Using GAITRite system to measure step length
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Step width
Using GAITRite system to measure step width
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Single support time
Using GAITRite system to measure single support time
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Gait Variability
Gait variability during continuous obstacle crossing will be assessed using the GaitUp system and expressed as the coefficient of variation (CV = standard deviation / mean × 100%) of step time and stride length.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Single-Leg Standing Balance
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Montreal Cognitive Assessment
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Participants receive 16 sessions of cognitive-motor training.
Participants receive 16 sessions of conventional physiotherapy.
Cognitive-motor training is that cognitive tasks incorporated into motor tasks.
Conventional physiotherapy includes ROM exercise, stretching, strengthening exercise, and eye-hand coordination.
National Yang Ming Chiao Tung University
Taipei, 112, Taiwan
First Submitted
October 24, 2026
First Posted
October 30, 2026
Study Start
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
August 31, 2029
Stride length
Using the GaitUp system to measure stride length during continuous obstacle-crossing walking.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Swing phase
Using the GaitUp system to measure swing phase during continuous obstacle-crossing walking.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Four Square Step Test
The Four Square Step Test is a test used to assess the ability to step over objects and measures the time in seconds to navigate all four squares.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Event-related potential - N2
Measure event-related potential through electroencephalography during the Go/No-go test
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Event-related potential - P300
Measure event-related potential through electroencephalography during the Go/No-go test
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Stroop color and word test
Record numbers of corrected color words which the subject responds within 45 sec.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Trail making test
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 30, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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