NCT07903688|Not Yet Recruiting
Meditation and Yogic Breathing-driven Modulation of Neurofluid Coupling and Brain Clearance
SPANDHA
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SPANDHA
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · Inner Science Research Foundation
interventional
120
1 country
1
Study Start
November 16, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
November 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study will examine whether meditation and yogic breathing can alter brain fluid movement and waste clearance in healthy adults. It will also evaluate the GLYMPHOMETER, a new external forehead-worn device designed to objectively measure changes in brain fluid movement and exchange during meditation.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 15, 2026
Actual (reported)October 29, 2026
Actual (reported)November 16, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
November 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Acquisition of physiological data using the GLYMPHOMETER during meditation and yogic breathing sessions.
Participants meeting threshold for analyzable device recordings.
At each study visit while the meditation is being practiced. Expected acquisition window: 20 minutes; Total number of visits: 2
Neurofluid-related physiological measures during Shoonya meditation and Nadi Shuddhi breathing.
At each study visit while the meditation is being practiced. Expected acquisition window: 20 minutes; Total number of visits: 2
Autonomic regulation during Shoonya meditation and Nadi Shuddhi breathing.
At each study visit while the meditation is being practiced. Expected acquisition window: 20 minutes; Total number of visits: 2
Very-low-frequency physiological signal characteristics
At each study visit while the meditation is being practiced. Expected acquisition window: 20 minutes; Total number of visits: 2
Differences in neurophysiological responses according to meditation experience.
From date of enrollment until end of both study visits; assessed up to 4 weeks from enrollment.
Mindful Attention Awareness Scale
Once at Baseline. Estimated acquisition window: 5-8 mins
Meditation Depth Questionnaires
At each study visit after the meditation practice is completed. Expected acquisition window: 10-15 minutes; Total number of visits: 2
Less than 1 year of consistent meditation practice.
More than 5 years or a minimum of 2500 hours of consistent meditation practice
Nadi Shuddhi is a structured yogic breathing practice involving slow, alternating respiration through the left and right nostrils in a prescribed sequence.
Shoonya meditation is a structured contemplative practice characterized by conscious non-doing, in which participants maintain a relaxed, alert state while minimizing deliberate attentional selection, cognitive elaboration, and engagement with internal or external stimuli.
BIDMC
Boston, Massachusetts, 02215, United States
First Submitted
September 15, 2026
First Posted
October 29, 2026
Study Start
November 16, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
November 30, 2027
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 29, 2026
Record last verified: 2026-09
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