Trials Sponsors Conditions Drugs Pricing

Conditions

Obsessive-Compulsive Disorder (OCD)Transcranial Magnetic Stimulation Electroencephalography

Outcome Measures

Primary Outcomes (1)

Symptom improvement assessed by the Yale-Brown Obsessive Compulsive Scale
The Yale-Brown Obsessive Compulsive Scale is a test to rate the severity of obsessive-compulsive disorder symptoms, which measures obsessions separately from compulsions. The scale includes 10 items, the first 5 items are evaluated obsessions, the rest are assessments compulsions. Each item 0-4 points, a total of 40 points. The lower the score, the better the outcome.
pre-treatment; 1-2 days post-treatment

Study Arms (1)

Active cTBS

EXPERIMENTAL

Device: Continuous Theta-Burst Stimulation

Interventions

Continuous Theta-Burst StimulationDevice

Continuous theta-burst stimulation (cTBS) is delivered to the individually localized right pre-supplementary motor area (pre-SMA) using a Magstim Rapid2 stimulator with a 70-mm figure-of-eight coil. The target is selected based on pretreatment resting-state fMRI connectivity with the right subthalamic nucleus, and coil placement is guided by neuronavigation. Stimulation consists of three-pulse bursts at 50 Hz repeated at 5 Hz, at 80% of the resting motor threshold. Three sessions of 600 pulses each are delivered daily at 15-minute intersession intervals, totaling 1,800 pulses per day, for 15 consecutive days.

Active cTBS

Eligibility Criteria

Age18 Years - 60 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64)

You may qualify if:

(1) age of 18-60 years; (2) OCD diagnosis confirmed by at least two psychiatrists; (3) a total score of ≥ 16 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or ≥ 10 for obsessions/compulsions only; and (4) medication-naïve status or a stable medication regimen followed for at least 2 weeks.

You may not qualify if:

Sponsors & Collaborators

Anhui Medical University
Otherlead

Study Sites (1)

Anhui Medical University

Hefei, Anhui, 230032, China

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Anxiety DisordersMental Disorders

Enrollment

60 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: The dean of the School of Mental Health and Psychological Sciences at Anhui Medical University

Study Record Dates

First Submitted

October 17, 2026

First Posted

October 27, 2026

Study Start

August 22, 2019

Actual (reported)

Continuous Theta-Burst Stimulation for Obsessive-Compulsive Disorder: An Open-Label Study

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Active cTBS

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Active cTBS

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

Source record

Locations