NCT06699706|Active Not Recruiting
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Sponsor study identifier
interventional
60
1 country
1
Study Start
November 1, 2024
Actual (reported)Primary Completion
October 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
November 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The aim of this clinical trial was to determine whether image-guided dual-target cTBS is effective for anxiety disorders. The main questions it aims to answer are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 1, 2024
Actual (reported)November 19, 2024
Actual (reported)November 21, 2024
Actual (reported)October 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Hamilton Anxiety Rating Scale (HAMA)
the change of anxiety symptoms assessed by HAMA scale(Hamilton Anxiety Scale) will constitute the major research outcome measure, to assess response to tACS. HAMA scale scores range from 0 to 56 points, the higher the score indicates the more serious anxiety symptoms
0week, 1week, 3week, 5week
Hamilton Depression Rating Scale (HAMD)
0week, 1week, 3week, 5week
Patient Health Questionnaire (PHQ-15)
0week, 1week
Self-rating anxiety scale(SAS)
0week, 1week
ISI(The insomnia severity index)
0week, 1week
Attention Network Test (ANT)
0week, 1week
Dual-target active cTBS will be performed over 7 consecutive days
Sham stimulation of dual-target cTBS was performed for 7 consecutive days using a sham coil
cTBS targets two regions: the dorsolateral prefrontal cortex (dlPFC) and the M1 area. Before the first treatment, each participant's resting motor threshold (RMT) will be determined using a five-step procedure for the primary motor cortex. RMT is defined as the minimum intensity required to elicit a motor response greater than 50 µV in at least 5 out of 10 consecutive trials in the right first dorsal interosseous muscle. Participants will then undergo daily cTBS treatment three times a day for 7 consecutive days. Each stimulation session lasts 40 seconds, consisting of triplets of 50 Hz theta-burst stimulation repeated at 5 Hz, delivering a total of 600 pulses. Stimulation of the dlPFC target will be immediately followed by stimulation of the M1 target. To achieve cumulative aftereffects, the protocol will be repeated three times per day (a total of 3600 pulses/day) with two 15-minute breaks between sessions, timed with a stopwatch.
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China
First Submitted
November 19, 2024
First Posted
November 21, 2024
Study Start
November 1, 2024
Actual (reported)Primary Completion
October 1, 2025
Estimated (date passed)Intervention Trial for Healthcare Workers With Anxiety
The treatment pattern for the sham continuous theta-burst stimulation was similar to that for real stimulation. The sham coil is identical in appearance to the active coil, but it only produces sounds and sensations similar to those of the active coil on the scalp without generating a current, preventing participants from identifying their group assignment.
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
November 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
August 22, 2025
Record last verified: 2025-08
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Source: ClinicalTrials.gov.
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