Trials Sponsors Conditions Drugs Pricing

Conditions

Nonspecific Chronic Low Back Pain

Outcome Measures

Primary Outcomes (1)

Pain-Related Evoked Potentials (amplitude)
Cortical pain habituation is acquired via pain-related evoked potentials (PREPs): time-locked neural responses to painful electrical stimuli derived from an ongoing EEG. Electrical pulses are delivered using a constant current via a custom-built concentric electrode taped onto the radial side of the dorsum of the non-dominate hand. The electrode is connected to the electrical stimulator, Digitimer DS7A (Digitimer Ltd, Welwyn Garden City, Hertfordshire, UK), which provides standardized, precisely-delivered electrical stimuli. EEG is collected using a BioSemi 32-channel ActiveTwo system using active-sensor Ag-AgCl electrodes (BioSemi, Amsterdam).
at time of subject enrollment

Secondary Outcomes (4)

Pain-Related Evoked Potentials (Habituation)
at time of subject enrollment
Pain Catastrophizing Scale
At time of subject enrollment
Five Facets of Mindfulness Questionnaire
At time of subject enrollment
Multidimensional Assessment of Interoceptive Awareness
At time of subject enrollment

Study Arms (2)

Healthy Controls

Healthy individuals ages 30-70 years old.

Nonspecific Chronic Low Back Pain

Individuals ages 30-70 years old with nonspecific chronic low back pain for at least 3 months with pain on at least half the days during the last 6 months.

Eligibility Criteria

Age30 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

Non-specific chronic low back pain (cLBP). Human participants with non-specific cLBP will be studied. Nonspecific cLBP is a broadly used-term to suggest that patient-reported pain cannot be explained by known tissue damage, inflammatory responses, or neuropathy. Enrolled participants will have experienced pain that has persisted for longer than 3 months and for at least half of the days during the past 6 months. Further, pain will interfere with activities of daily life and participation in social roles.

You may qualify if:

Sponsors & Collaborators

National Center for Complementary and Integrative Health (NCCIH)
NIHcollaborator
Oregon Health and Science University
Otherlead

Study Sites (1)

Oregon Health and Science University

Portland, Oregon, 97229, United States

Biospecimen

Retention: SAMPLES WITHOUT DNA

saliva cortisol

Study Officials

Barry D Oken, MD, PhD
Oregon Health and Science University
PRINCIPAL INVESTIGATOR

Enrollment

26 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor

Study Record Dates

First Submitted

April 26, 2019

First Posted

October 27, 2026

Study Start

April 1, 2019

Actual (reported)

Body and the Brain: Cortical Reactivity and Cognitive-Affective Regulation to Experimental Pain.

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

Primary Completion

Study Completion

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Healthy Controls

Nonspecific Chronic Low Back Pain

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

Primary Completion

Study Completion

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Healthy Controls

Nonspecific Chronic Low Back Pain

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations