NCT07895589|Not Yet Recruiting
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
SELDISC
SELDISC - A Trial on SELective Nerve Root Block for Lumbar DISC Herniation
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SELDISC
SELDISC - A Trial on SELective Nerve Root Block for Lumbar DISC Herniation
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · Region Stockholm (ALF funding)
OTHER_GRANT · CIMED, Karolinska Institutet
interventional
262
1 country
2
Study Start
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
January 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back. A herniated disc can irritate a nerve and cause pain that travels down the leg. A nerve root block delivers a local anaesthetic and a corticosteroid near the affected nerve to relieve pain and inflammation. The study will include 262 adults aged 18-66 years who have persistent leg symptoms despite non-surgical treatment and have been assessed by a spine surgeon as eligible for surgery. Participants will be randomly assigned to receive either a selective nerve root block or a sham procedure that mimics the treatment without delivering the active medication near the nerve. Each participant will have an equal chance of receiving either procedure. Participants and the study staff assessing their outcomes will not know which procedure was given. The radiologist performing the procedure will know the allocation. The main question is whether fewer participants in the nerve root block group undergo surgery within 12 months after randomisation. The study will also compare pain, disability, quality of life, time to surgery, medication use, sick leave, healthcare use and adverse events between the groups.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 17, 2026
Actual (reported)October 26, 2026
Actual (reported)January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Proportion of participants undergoing lumbar disc surgery
Proportion of participants who undergo surgery for the index lumbar disc herniation within 12 months after randomisation. The outcome is recorded for each participant as yes or no.
Within 12 months after randomisation
Time to lumbar disc surgery
From randomisation to 12 months
Leg pain intensity measured using the Visual Analogue Scale
Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Participants will receive a fluoroscopy-guided selective nerve root block at the affected lumbar nerve root, with injection of a local anaesthetic and a corticosteroid.
Participants will undergo a sham procedure that reproduces the preparation, superficial local anaesthesia and image-guided needle placement of the active intervention, without administering any injectate near the nerve root.
Fluoroscopy-guided needle placement at the affected lumbar nerve root, followed by contrast administration to confirm needle position and injection of a local anaesthetic and a depot corticosteroid.
Superficial local anaesthesia and fluoroscopy-guided needle placement to mimic a selective nerve root block, without contrast or therapeutic injectate administration near the nerve root.
Karolinska University Hospital
Stockholm, Sweden
Stockholm Center for Spine Surgery (RKC)
Stockholm, Sweden
First Submitted
October 17, 2026
First Posted
October 26, 2026
Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique in Lumbar Radiculopathy
Back pain intensity measured using the Visual Analogue Scale
Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Leg pain intensity measured using the Numeric Rating Scale
Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Back pain intensity measured using the Numeric Rating Scale
Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Long-term lumbar disc surgery
From randomisation to 5 years
Long-term reoperations
From randomisation to 5 years
Long-term complications
From randomisation to 5 years
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Study Start
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
January 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 27, 2026
Record last verified: 2026-10
IPD underlying published manuscripts will be accessible for other researchers. The investigators in charge will be responsible for reviewing access requests. Crude data, randomization procedures and intervention details can be shared with other researchers upon reasonable request.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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