Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
1 other identifier
interventional
60
1 country
1
Brief Summary
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection. However, complete disinfection remains difficult because of the complex anatomy of the root canal system, allowing residual microorganisms to persist and contribute to persistent apical periodontitis and treatment failure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 25, 2026
CompletedFirst Submitted
Initial submission to the registry
October 18, 2026
CompletedFirst Posted
Study publicly available on registry
October 23, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 15, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 30, 2027
October 23, 2026
September 1, 2026
12 months
October 18, 2026
October 18, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Anti-Microbial efficacy assessment
Assessment of The paper points of the Participants by quantitative microbiological analysis using colony-forming units (CFU/mL). and will be incubated and will be determined by bacterial counting using agar culture technique before and after root canal preparation (CFU/ml).
7 days
Secondary Outcomes (1)
Post Operative Pain
7 days
Study Arms (3)
Control Group
EXPERIMENTALabout 20 participants will be subjected to Calcium hydroxide mixed with sterile saline for intracanal placement
Cyperus articulatus
EXPERIMENTALabout 20 participants will be subjected to Cyperus articulates essential oil mixed with inert gel for intracanal placement.The amount of essential oil used will be standardized for all specimens to ensure uniform consistency and reproducibility.
Calcium Hydroxide Mixed with Cyperus articulatus
EXPERIMENTALabout 20 participants will be subjected to Calcium hydroxide powder will be mixed with Cyperus articulatus essential oil using the same standardized powder-to-liquid ratio adopted in the control group until a smooth, homogeneous paste with adequate consistency is achieved.The amount of essential oil used will be standardized for all specimens to ensure uniform consistency and reproducibility.
Interventions
to evaluate the effect of Cyperus articulatus versus Calcium hydroxide on bacterial reduction and postoperative pain in necrotic permanent teeth with chronic apical periodontitis
Eligibility Criteria
You may qualify if:
- Healthy adult Patient.
- Medically free patients.
- Mandibular permanent premolar teeth:
- Diagnosed clinically with necrotic pulp.
- Absence of pain.
- Radiographic evidence of chronic apical periodontitis .
- Radiographic evidence of single root with single canals.
- Normal occlusal contact with opposing teeth.
- Patients' acceptance to participate in the trial.
You may not qualify if:
- Medically compromised patients having significant systemic disorders (ASA III or IV).
- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
- Pregnant women: to avoid radiation exposure, anaesthesia, medication and hormonal fluctuation that might increase pain prevalence.
- Patients reporting bruxism, clenching, TMJ problems or traumatic occlusion: to avoid further pressure on inflamed tooth which induce subsequent irritation and inflammation.
- Patients with two or more adjacent teeth requiring endodontic treatment.
- Teeth that requires further procedural steps or multidisciplinary approach, which is out of this experiment's scope:
- i. Association with swelling or fistulous tract. ii. Acute periapical abscess. iii. Mobility Grade II or III. iv. Pocket depth more than 5mm. v. Previous root canal treatment. vi. Non-restorable. vii. Immature root. viii. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.
- Inability to perceive the given instructions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Minia Universitylead
Study Sites (1)
Endodontics Department Faculty of Dentistry,Minia University
Minya, Egypt
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Rehab Mahmoud Abdel Baky Radwan, M.D
Professor of Microbiology and Immunology,Faculty of Pharmacy,Deraya University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Specialist at department of Endodontics, Faculty of Dentistry
Study Record Dates
First Submitted
October 18, 2026
First Posted
October 23, 2026
Study Start
September 25, 2026
Primary Completion (Estimated)
September 15, 2027
Study Completion (Estimated)
September 30, 2027
Last Updated
October 23, 2026
Record last verified: 2026-09