Tai Chi Training for Persons With Multiple Sclerosis.

NCT07890974 | Active Not Recruiting

• 2 other identifiers: 2023-03661-012023
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Tai Chi combines strength and neuromuscular training with diaphragmatic breathing, attention, imagery and relaxation. After an initial learning period, participants can practise independently, potentially supporting self-efficacy and sustained self-management. Studies in chronic disease report benefits for physical function and psychological wellbeing. We will evaluate a 12-week Tai Chi rehabilitation programme in a clincial trial. The Multiple Sclerosis Impact Scale (MSIS-29) is the primary clinical outcome, reflecting the physical and psychological consequences of multiple sclerosis (MS). Assessments take place before training and at 12 weeks (the primary endpoint). The study will address whether Tai Chi improves physical and mental health; reduces fatigue, anxiety, depression and pain; improves lower-limb strength, gait and balance; and improves quality of life and self-efficacy.

Conditions

Multiple Sclerosis (MS) - Relapsing-remitting

Keywords

multiple sclerosis; rehabilitation; physical health; mental health

Outcome Measures

Primary Outcomes (1)

• MSIS-29

  MSIS-29 assesses the physical and psychological impact of MS

  From enrollment to the end of treatment at 12 weeks

Study Arms (1)

Tai Chi training

OTHER

Other: Tai Chi training

Interventions

Tai Chi training OTHER

Training comprises three components: warm-up exercises to improve mobility and flexibility, reduce tension and introduce relaxed breathing; simple Tai Chi movements and a short sequence to develop coordinated, gentle weight shifts; and Standing like a Tree Qigong to develop upright posture, relaxation and breathing awareness. The programme teaches foundational skills and supports regular practice that can be integrated into daily living.

Tai Chi training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Stockholm, Sweden

Location

MeSH Terms

Conditions

Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis; Psychological Well-Being

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Personal Satisfaction; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Associate Professor

Study Record Dates

• First Submitted: October 18, 2026
• First Posted: October 23, 2026
• Study Start: March 1, 2025
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): March 1, 2028
• Last Updated: October 23, 2026

Record last verified: 2026-10

Locations

SE (1)