NCT07888036|Not Yet Recruiting
Neutrophil Activation and NETosis in Sepsis
Evaluation of Neutrophil Activation and NETosis in Patients With Sepsis and Their Association With Clinical Outcomes
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Evaluation of Neutrophil Activation and NETosis in Patients With Sepsis and Their Association With Clinical Outcomes
Sponsor study identifier
observational
85
0 countries
N/A
Study Start
October 20, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 20, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This prospective observational study aims to evaluate neutrophil activation markers and circulating citrullinated histone H3 levels in adult patients with sepsis or septic shock.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 15, 2026
Actual (reported)October 20, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 22, 2026
Actual (reported)October 20, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
March 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Citrullinated histone H3 level
Mean plasma citrullinated histone H3 level measured by enzyme-linked immunosorbent assay.
Baseline
CD66b expression
Baseline
CD15 expression
Baseline
Platelet count
Baseline
Number of deaths
At 28 days
Adult patients with sepsis or septic shock undergoing assessment of neutrophil activation markers and citrullinated histone H3 levels.
Adult patients aged 18 years or older with sepsis or septic shock enrolled within 24 hours of diagnosis or admission to the intensive care unit at Assiut University Hospital.
Hanan G abdel azeem, prof
Clinical pathology Department, Assiut University Hospitals
Radwa H Nagib, Prof
Clinical pathology Department, Assiut University Hospitals
First Submitted
October 15, 2026
First Posted
October 22, 2026
Study Start
October 20, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Contact the study team to confirm eligibility.
October 20, 2027
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 22, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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