Effects of Probiotics on Skin Health in Healthy Women
A Randomised, Double-Blind, Placebo-Controlled Clinical Investigation to Evaluate the Effects of an Oral Probiotic Supplement in Healthy Adult Women With Clinically Dry to Very Dry Facial Skin.
1 other identifier
interventional
140
1 country
1
Brief Summary
The effect of probiotics on skin health in healthy women with dry to very dry facial skin.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Oct 2026
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2026
CompletedFirst Submitted
Initial submission to the registry
October 12, 2026
CompletedFirst Posted
Study publicly available on registry
October 21, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 1, 2027
October 21, 2026
October 1, 2026
7 months
October 12, 2026
October 19, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
PRIMOS CR crow's-feet wrinkle depth
12 weeks
Study Arms (2)
Probiotics
ACTIVE COMPARATORPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Female, of self-reported Caucasian ethnicity, aged 35 to 45 years at the time of informed consent
- Fitzpatrick skin type II-IV
- Mean MoistureMeterSC value of ≤30 obtained at the Baseline Visit before randomisation
- Generally healthy
You may not qualify if:
- Significant facial dermatological condition that may interfere with study assessments
- Uncontrolled or clinically significant medical condition that may compromise participant safety or interpretation of study outcomes
- Known allergy, intolerance or hypersensitivity to any active ingredient, excipient or component of the study product or placebo
- Use of prohibited medications, nutritional supplements or cosmetic/dermatological procedures
- Current participation in another interventional clinical study, or participation in another interventional study within the previous 30 days.
- Lifestyle, skincare or cosmetic factors likely to interfere with study assessments or interfere with instrumental or imaging assessment
- Pregnant, breastfeeding or planning pregnancy during the study period.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Probi ABlead
Study Sites (1)
Sequential Skin Ltd
Babraham, CB22 3AT, United Kingdom
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 12, 2026
First Posted
October 21, 2026
Study Start
October 1, 2026
Primary Completion (Estimated)
May 1, 2027
Study Completion (Estimated)
May 1, 2027
Last Updated
October 21, 2026
Record last verified: 2026-10
Data Sharing
- IPD Sharing
- Will not share