Physical Performance and Cognitive Functions in Patients With Chronic Stroke

NCT07887776 | Completed

• 1 other identifier: KSBU 2024/11-08
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the impact of cognitive impairment on upper extremity physical performance, cognitive skills, and functional independence in individuals with chronic stroke. A total of 66 chronic stroke survivors will be enrolled and categorized into two groups based on their Montreal Cognitive Assessment (MoCA) scores: the Cognitive Impairment Group (n=33) and the Control Group (n=33). Upper extremity performance, cognitive functions, and functional independence will be comprehensively evaluated using standardized clinical outcome measures.

Conditions

Stroke

Keywords

Cronic stroke; cognitive impairment; upper extremity; motor performance; functional independence

Outcome Measures

Primary Outcomes (4)

• Wolf Motor Function Test (WMFT) Performance Time

  valuates upper extremity motor ability and functional performance through timed and functional tasks. WMFT performance time is measured in seconds, where longer durations indicate lower performance.

  Baseline (Single assessment session)

• Fugl-Meyer Upper Extremity Assessment (FM-UE) Score

  Measures motor recovery, reflex activity, and movement coordination in the upper extremity. Scores range from 0 to 66, with higher scores indicating better motor function.

  Baseline (Single assessment session)

• Box and Block Test (BBT) Score

  Assesses unilateral manual dexterity. It measures the number of blocks transported from one compartment to another within 60 seconds (evaluated separately for affected and unaffected upper extremities).

  Baseline (Single assessment session)

• Functional Independence Measure (FIM) Motor and Cognitive Sub-scores

  Evaluates the level of independence in activities of daily living. It consists of motor and cognitive sub-scales, where higher scores reflect greater functional independence.

  Baseline (Single assessment session)

Secondary Outcomes (2)

• Stroop Test Completion Times

  Baseline (Single assessment session)

• Forward and Backward Digit Span Test Scores

  Baseline (Single assessment session)

Study Arms (2)

Cognitive Impairment Group

Scoring 20 or lower on the Montreal Cognitive Assessment (MoCA)

Control Group

Scoring 21 or higher on the Montreal Cognitive Assessment (MoCA)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population comprises adult patients of both genders, aged between 18 and 80 years, who have experienced a single ischemic or hemorrhagic stroke at least six months prior to enrollment (chronic stroke phase). Participants are recruited from outpatient physical therapy and rehabilitation clinics. Based on their cognitive screening using the Montreal Cognitive Assessment (MoCA), the study population is categorized into two comparative cohorts: a Cognitive Impairment Group and a Control Group. Eligible participants must be able to communicate effectively, be literate, and have no pre-existing cognitive disorders, severe medical comorbidities, or concurrent neurological/orthopedic conditions that could independently affect physical or cognitive performance.

You may qualify if:

• History of ischemic or hemorrhagic stroke diagnosed at least 6 months prior to the study,
• First-ever stroke
• Absence of communication or language disorders that would prevent understanding and cooperation
• Ability to read and write
• Not currently receiving psychotropic medication treatment
• Willingness to participate and provision of signed informed consent

You may not qualify if:

• Having a chronic and severe medical condition (e.g., epilepsy, cerebral palsy)
• Presence of any other concurrent orthopedic or neurological disease affecting physical or cognitive performance
• History of recent surgery
• History of any pre-existing condition affecting cognitive status (e.g., dementia, neurodegenerative diseases)
• Complete loss of vision or hearing

Sponsors & Collaborators

• Kutahya Health Sciences University: lead

Study Sites (1)

Doç. Dr. Mustafa Kalemli Tavsanli State Hospital

Kütahya, Tavşanlı, 43300, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Stroke; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assit. Prof.

Study Record Dates

• First Submitted: October 15, 2026
• First Posted: October 21, 2026
• Study Start: January 1, 2025
• Primary Completion: June 30, 2026
• Study Completion: July 1, 2026
• Last Updated: October 21, 2026

Record last verified: 2026-10

Locations

TU (1)