KET-OLD-M
Sponsor study identifier
interventional
18
0 countries
N/A
Study Start
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older trained males. This trial will compare the difference in phenylalanine metabolism between the ketone monoester and control conditions. Secondary outcomes including plasma amino acid, plasma insulin, plasma glucose, capillary blood beta-hydroxybutyrate concentrations and whole body myofibrillar protein breakdown rate (k) will be explored as secondary measures. Ketone monoester supplementation with protein in the post-resistance exercise period will be compared to the control condition of just protein in the post-resistance exercise period.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 13, 2026
Actual (reported)October 20, 2026
Actual (reported)November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Phenylalanine Oxidation
Quantification of whole-body phenylalanine oxidation using 13CO2 enrichment measured in breath samples following ingestion of labeled phenylalanine.
0-360 minutes in the postprandial period
Phenylalanine Retention
Quantification of whole-body phenylalanine retention calculated as the difference between phenylalanine intake and total exogenous phenylalanine oxidation following ingestion of labeled phenylalanine.
0-360 minutes in the postprandial period
Incremental area under the curve for total amino acid concentration
60 minutes pre-prandial to 360 minutes postprandial
0.36 g/kg body weight of Ketone monoester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate and 0.3 g of protein/kg body weight from whey protein hydrolysate dissolved in 250 mL of sugar-free Powerade with the addition of stevia and bitters to improve and homogenize taste between treatments.
0.3 g of protein/kg body weight from whey protein hydrolysate dissolved in 250 mL of sugar-free Powerade with the addition of stevia to improve and homogenize taste between treatments.
Ketone monoester supplement (R)-3-hydroxybutyl (R)-3-hydroxybutyrate based on participants' body weight (0.36g/kg body weight). Protein at a dose of 0.3 g/kg body weight protein. The protein component will come from whey protein hydrolysate. The ketone brand name: delta G Oxford Ketone Ester
Protein at a dose of 0.3 g/kg body weight protein in the form of whey protein hydrolysate.
Tyler Churchward-Venne
Department of Kinesiology and Physical Education, McGill University
First Submitted
October 13, 2026
First Posted
October 20, 2026
Study Start
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
Time-course data for total amino acid concentration
60 minutes pre-prandial to 360 minutes postprandial
Incremental area under the curve for essential amino acid concentration
60 minutes pre-prandial to 360 minutes postprandial
Time-course data for essential amino acid concentration
60 minutes pre-prandial to 360 minutes postprandial
Incremental area under the curve for branched chain amino acid concentration
60 minutes pre-prandial to 360 minutes postprandial
Full body exercise session consisting of a 5 minute treadmill run and 5 minute multi-joint stretch session consisting of a pectoral stretch, latissimus dorsi stretch, a quadriceps stretch and a hamstring stretch followed by the following exercises: machine chest press, machine seated row, machine shoulder press, machine quadriceps extension, machine hamstrings curl, and machine abdominal crunch performed for 3 sets of 8 repetitions each performed at 80% of 1RM, with 2 repetitions in reserve.
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April 2027
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 20, 2026
Record last verified: 2026-05
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Source: ClinicalTrials.gov.
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