NCT07884500|Recruiting
Temporal Dynamics of Peripheral SpO₂ During Reoxygenation
PulseOx
Loading search results
PulseOx
Sponsor study identifier
interventional
100
1 country
1
Study Start
August 3, 2026
Actual (reported)Primary Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Pulse oximeters estimate arterial oxyhaemoglobin saturation (SaO₂) from photoplethysmographic signals recorded at peripheral sites (usually the fingertip), thus measuring the peripheral oxygen saturation (SpO₂). They are ubiquitous in emergency medicine because they offer a non-invasive, continuous measure of oxygenation and can alert clinicians to impending hypoxaemia, both during procedures such as rapid sequence intubation or sedation, or for continuous monitoring of patients. However, the accuracy of SpO₂ is often assumed to be instantaneous. This assumption is particularly hazardous during critical events involving rapid desaturation and resaturation. In such situations clinicians use SpO₂ readings to decide when to stop an apnea period during laryngoscopy and commence reoxygenation. If there is a delay between actual arterial desaturation and the displayed SpO₂, the clinician may not recognise hypoxaemia in time or may resume ventilation too late.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 3, 2026
Actual (reported)September 14, 2026
Actual (reported)October 20, 2026
Actual (reported)February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Evaluation of SpO₂ Resaturation Following Voluntary Apnea
To characterize the temporal behavior of a modern finger pulse oximeter during voluntary apnea in healthy volunteers, with a particular focus on the delay (in seconds) between physiological reoxygenation and displayed SpO₂ (Time interval in seconds between the first breath following apnea and the first increase in SpO2.)
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
Comparison of SpO₂ Temporal Parameters Between Finger and Ear Sensors
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
Quantification of SpO₂ Measurement Delay Between Measurement Sites
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
Assessment of Intra-Individual Measurement Variability
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
Evolution of the Perfusion Index (PI) during Apnea and Reoxygenation by finger/auricular pulse oximeter
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
Physiological Factors Associated with SpO₂ Response Delay
From enrollment to the end of the inclusion, estimated at approximately 10 months from the start of enrollment
After a 5-minute resting period, two pulse oximetry sensors will be placed simultaneously: a finger sensor and an ear sensor (earlobe). Baseline parameters will be recorded. The apnea protocol will consist of a maximal inspiration followed by voluntary breath-holding. Throughout the procedure, oxygen saturation (SpO₂), heart rate, and perfusion index will be continuously recorded until the values return to baseline. The monitor screens will be video-recorded to allow precise temporal analysis of events (onset of apnea, resumption of breathing, desaturation, nadir, and resaturation). After a further 5-minute resting period, the procedure will be repeated a second time.
Two pulse oximetry sensors (finger and earlobe) will be simultaneously applied, and baseline oxygen saturation (SpO₂), heart rate, and perfusion index will be recorded. The participant will then perform two voluntary apnea tests, during which these parameters will be continuously monitored to assess the timing of apnea, desaturation, nadir, and resaturation.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
First Submitted
September 14, 2026
First Posted
October 20, 2026
Study Start
August 3, 2026
Actual (reported)Primary Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Sleep Apnea and Visual Perceptual Skill Learning
Ventilation Using a Bag Valve Mask With Integrated Internal Handle
Contact the study team to confirm eligibility.
Study Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 20, 2026
Record last verified: 2026-10
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: