Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects

NCT03095677 | Completed

• 1 other identifier: CHRO-2015-01
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training. The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.

Conditions

Apnea

Keywords

dynamic apnea; muscle oxygenation; physical performance

Outcome Measures

Primary Outcomes (9)

• Spectometry to measure hemoglobin rate

  Measurement of oxygenation

  3 weeks

• Wingate test to measure maximum consumption of dioxygen

  Measurement of aerobic performance

  3 weeks

• Measurement of hormonal markers

  Measurement of Dehydroepiandrostenedione (DHEA)

  3 weeks

• Jaeger debimeter system to measure of peak oxygen

  Measurement of oxygen consumptiom

  3 weeks

• Measurement of arterial saturation in dioxygen

  Measurement by ear blood micro-sample

  3 weeks

• Spectometry to measure hemoglobin

  Measurement of oxygenation

  12 weeks

• Measurement of hormonal markers

  Measurement of Dehydroepiandrostenedione (DHEA)

  12 weeks

• Jaeger debimeter system to measure of peak oxygen

  Measurement of oxygen consumption,

  12 weeks

• Measurement of arterial saturation in dioxygen

  Measurement by ear blood micro-sample

  12 weeks

Secondary Outcomes (4)

• Cardiac frequency

  3 weeks

• Cardiac frequency

  12 weeks

• Borg scale to measure penibility of the effort

  week 3

• Borg scale to measure penibility of the effort

  week 12

Study Arms (2)

Apnea Group (GApn)

EXPERIMENTAL

Program of training with exercises including apneas

Other: Program of training with exercises including apnea

Control Group (GC)

OTHER

Program of training with exercises without apnea

Other: Program of training with exercises without apnea

Interventions

Program of training with exercises including apnea OTHER

16 training session on cycle ergometry with exercises including apneas.

Apnea Group (GApn)

Program of training with exercises without apnea OTHER

16 training session on cycle ergometry with exercises without apnea

Control Group (GC)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
• Subjects will have to sign the inform consent before the beginning of the study

You may not qualify if:

• Contraindications to regular physical exercise practice
• To practice an endurance sport more than 1h/week
• Regular practice of apnea
• Chronic use of cannabis and/or alcohol
• Cardiac or metabolic pathology
• Asthma and/or bronchodilatator treatment
• ECG abnormality at rest
• Regular consumption of tobacco

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead
• Laboratoire de Complexité, Innovation et Activités Motrices et Sportives: collaborator

Study Sites (1)

CHR d'Orléans

Orléans, 45067, France

Location

Related Publications (4)

• Andersson JP, Liner MH, Runow E, Schagatay EK. Diving response and arterial oxygen saturation during apnea and exercise in breath-hold divers. J Appl Physiol (1985). 2002 Sep;93(3):882-6. doi: 10.1152/japplphysiol.00863.2001.

  PMID: 12183481 BACKGROUND

• Caquelard F, Burnet H, Tagliarini F, Cauchy E, Richalet JP, Jammes Y. Effects of prolonged hypobaric hypoxia on human skeletal muscle function and electromyographic events. Clin Sci (Lond). 2000 Mar;98(3):329-37.

  PMID: 10677392 BACKGROUND

• de Bruijn R, Richardson M, Schagatay E. Increased erythropoietin concentration after repeated apneas in humans. Eur J Appl Physiol. 2008 Mar;102(5):609-13. doi: 10.1007/s00421-007-0639-9. Epub 2007 Dec 19.

  PMID: 18097682 BACKGROUND

• Dufour SP, Ponsot E, Zoll J, Doutreleau S, Lonsdorfer-Wolf E, Geny B, Lampert E, Fluck M, Hoppeler H, Billat V, Mettauer B, Richard R, Lonsdorfer J. Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol (1985). 2006 Apr;100(4):1238-48. doi: 10.1152/japplphysiol.00742.2005.

  PMID: 16540709 BACKGROUND

MeSH Terms

Conditions

Apnea

Interventions

Exercise

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Virgile AMIOT, Ph

  CHR ORLEANS

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 27, 2016
• First Posted: March 30, 2017
• Study Start: April 8, 2016
• Primary Completion: November 20, 2017
• Study Completion: November 20, 2017
• Last Updated: May 7, 2018

Record last verified: 2018-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)