Disease Intervention Specialist (DIS) for SUD

NCT07875361 | Not Yet Recruiting DMC

• 2 other identifiers: STUDY20252142U01CE003823
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study evaluates three Disease Intervention Specialist service models designed to proactively identify and support adults at risk for substance use disorder. The models include substance use screening, motivational interviewing, case management, treatment referral, and optional peer support. The study will compare participant outcomes across the service models, including substance use severity, treatment engagement, overdose, service utilization, and satisfaction.

Conditions

Substance Use Disorder (SUD); Opioid Use Disorder; Alcohol Use Disorder (AUD); Drug Use; Overdose

Keywords

substance use disorder; disease intervention specialist; public health; contact tracing; peer navigation; substance use treatment; public health outreach

Outcome Measures

Primary Outcomes (1)

• Severity of Drug Use

  Change in substance use severity among participants receiving DIS-based SUD interventions -substance use severity will be assessed using the NIDA-Modified ASSIST (NM-ASSIST)

  6 months post initial DIS interview

Secondary Outcomes (5)

• Linkage to Substance Use Disorder Treatment

  Within 3 months of initial DIS interview

• Retention in SUD treatment

  6 months after initial DIS interview

• Number of Social Contacts Elicited per Index Participant

  During DIS intervention period (up to 3 months)

• Number of Healthcare and Substance Use Treatment Encounters

  From baseline through 6 months post-initial DIS interview

• Percentage of Participants Attending at Least One SUD Treatment Visit

  6 months post-initial DIS interview

Study Arms (3)

Model 1: Integrated Infectious Disease DIS+SUD Intervention

Participants receive services through an existing infectious disease DIS program in which substance use disorder (SUD) screening, motivational interviewing, case management, referral to treatment, and social network outreach are integrated into routine infectious disease investigation activities.

Model 2: SUD Specific DIS Intervention

Participants receive services through a DIS program dedicated specifically to substance use disorder prevention and intervention. Services include SUD screening, motivational interviewing, case management, referral to treatment providers, and social network-based outreach.

Model 3: SUD DIS Intervention with Peer Support

Participants receive the same SUD-focused DIS intervention as Model 2, with the addition of trained peer support specialists. Peer navigators assist with outreach, rapport building, appointment support, treatment navigation, reminders, and overcoming barriers to care.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Columbus Public Health DIS programs * Emergency Department referrals * Community Agencies * Social-network outreach

You may qualify if:

• age: must be 18 years or older at the time of screening
• language: must be English-Speaking
• Capacity and willingness to participate
• SUD risk or diagnosis
• Not already in SUD care

You may not qualify if:

• Non-English Speaking
• Currently engaged in formal substance use disorder treatment at the time of initial DIS contact
• Low risk or does not have a current substance use disorder diagnosis

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Conditions

Substance-Related Disorders; Opioid-Related Disorders; Alcoholism; Drug Overdose

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Narcotic-Related Disorders; Alcohol-Related Disorders; Prescription Drug Misuse; Drug Misuse

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 23, 2026
• First Posted: October 15, 2026
• Study Start (Estimated): December 1, 2026
• Primary Completion (Estimated): September 1, 2029
• Study Completion (Estimated): September 29, 2030
• Last Updated: October 15, 2026

Record last verified: 2026-09

Locations

US (1)