Functional Capacity Differences in Knee Osteoarthritis With Similar Pain Severity

NCT07869680 | Recruiting

• 1 other identifier: MEAH-PMR-TYY1
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

People with knee osteoarthritis may have similar levels of pain but very different abilities to walk, rise from a chair, and perform daily activities. This study aims to examine the factors associated with these differences in functional capacity among patients with similar knee pain severity. Adults with radiographic knee osteoarthritis and an average knee pain level of 4-6 on a 0-10 scale will be included. During a single study visit, participants will complete questionnaires about physical function, central sensitization-related symptoms, and physical activity. They will also perform a 10-meter walk test, a 30-second chair stand test, and the Timed Up and Go test. Self-reported physical function will be assessed using the function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index. Participants with better and poorer function will be compared, and the clinical factors independently associated with functional capacity will be examined. No treatment or intervention will be assigned as part of this study.

Conditions

Knee Osteoarthritis

Keywords

Functional Capacity; Central Sensitization; Physical Activity; Western Ontario and McMaster Universities Osteoarthritis Index; Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Self-Reported Physical Function Assessed by the WOMAC Function Subscale

  Self-reported functional limitation will be assessed using the 17-item function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Each item is scored from 0 to 4, producing a total score ranging from 0 to 68. Higher scores indicate greater functional limitation and worse physical function.

  Baseline

Secondary Outcomes (5)

• Walking Speed Assessed by the 10-Meter Walk Test

  Baseline

• Chair Stand Performance Assessed by the 30-Second Chair Stand Test

  Baseline

• Functional Mobility Assessed by the Timed Up and Go Test

  Baseline

• Central Sensitization-Related Symptom Burden Assessed by the Central Sensitization Inventory

  Baseline

• Weekly Physical Activity Duration

  Baseline

Study Arms (1)

Patients With Knee Osteoarthritis

Adults aged 40-75 years with clinical and radiographic knee osteoarthritis of Kellgren-Lawrence grade 2 or 3 and an average knee pain intensity of 4-6 on a 0-10 visual analog scale during the previous week.d.

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adults attending the Physical Medicine and Rehabilitation outpatient clinic of Mardin Training and Research Hospital with clinical and radiographic knee osteoarthritis. Only patients with Kellgren-Lawrence grade 2 or 3 disease and similar moderate knee pain severity will be included. No healthy control group will be enrolled.

You may qualify if:

• Age 40-75 years
• Clinical and radiographic diagnosis of knee osteoarthritis
• Kellgren-Lawrence grade 2 or 3 knee osteoarthritis
• Knee pain lasting at least 3 months
• Average knee pain intensity during the previous week between 4 and 6 on a 0-10 visual analog scale
• Ability to provide written informed consent

You may not qualify if:

• Kellgren-Lawrence grade 1 or 4 knee osteoarthritis
• Inflammatory rheumatic disease
• History of knee surgery or intra-articular knee injection within the previous 6 months
• Neurological disease that substantially affects knee function
• Severe cardiopulmonary disease that prevents walking or performance testing
• Cognitive impairment that prevents participation in the assessment procedures
• For participants with bilateral knee osteoarthritis, assessments will be performed on the more painful knee.

Sponsors & Collaborators

• Mardin Artuklu University: lead
• Mardin Training and Research Hospital: collaborator

Study Sites (1)

Mardin Training and Research Hospital

Mardin, 47100, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Tuzun EH, Eker L, Aytar A, Daskapan A, Bayramoglu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthritis Cartilage. 2005 Jan;13(1):28-33. doi: 10.1016/j.joca.2004.10.010.

  PMID: 15639634 BACKGROUND

• White DK, Tudor-Locke C, Zhang Y, Fielding R, LaValley M, Felson DT, Gross KD, Nevitt MC, Lewis CE, Torner J, Neogi T. Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study. Arthritis Care Res (Hoboken). 2014 Sep;66(9):1328-36. doi: 10.1002/acr.22362.

  PMID: 24923633 BACKGROUND

• Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018.

  PMID: 23973124 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee; Motor Activity

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Behavior

Central Study Contacts

Taha Yasin YILDIRIM, M.D.

CONTACT

+90 534 220 77 17; tyasinyildirim.ftr@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: October 6, 2026
• First Posted: October 9, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: October 9, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)