Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis

NCT07381621 | Recruiting

• 2 other identifiers: AnkaraTRH-FTR-NK-102024-KAEK-40
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 2

Brief Summary

This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.

Conditions

Knee Osteoarthritis

Keywords

Perineural Injection; Dextrose Injection; Local Anesthetic Injection; Pain; WOMAC; Observational Study

Outcome Measures

Primary Outcomes (1)

• Change in Knee Pain Intensity (Visual Analog Scale [VAS])

  Change in Knee Pain Intensity (Visual Analog Scale \[VAS\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain.

  Baseline, 1 month, 3 months, and 6 months

Secondary Outcomes (3)

• Change in Functional Status (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC])

  Baseline, 1 month, 3 months, and 6 months

• Change in Knee Range of Motion

  Baseline, 1 month, 3 months, and 6 months

• Change in Quadriceps Muscle Strength

  Baseline, 1 month, 3 months, and 6 months

Study Arms (2)

Perineural 5% Dextrose Group

Patients with symptomatic knee osteoarthritis receiving perineural 5% dextrose injections as part of routine clinical care.

Procedure: Perineural 5% Dextrose Injection

Perineural Local Anesthetic Group

Patients with symptomatic knee osteoarthritis receiving perineural local anesthetic injections as part of routine clinical care.

Procedure: Perineural Local Anesthetic Injection

Interventions

Perineural 5% Dextrose Injection PROCEDURE

Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.

Perineural 5% Dextrose Group

Perineural Local Anesthetic Injection PROCEDURE

Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.

Perineural Local Anesthetic Group

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 40 to 65 years with symptomatic knee osteoarthritis who are receiving perineural injection therapy as part of routine clinical care. Eligible participants include both male and female patients who meet the predefined inclusion and exclusion criteria and are able to provide written informed consent.

You may qualify if:

• Symptomatic knee osteoarthritis
• Clinical/radiological diagnosis
• Knee pain ≥ 3 months
• Written informed consent

You may not qualify if:

• Prior knee surgery
• Recent intra-articular injection
• Inflammatory rheumatic disease
• Severe systemic or neurological disease
• Pregnancy or breastfeeding

Sponsors & Collaborators

• Ankara Training and Research Hospital: lead

Study Sites (2)

Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230

Ankara, Altindag, 06230, Turkey (Türkiye)

NOT YET RECRUITING

Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230

Ankara, Altindag, 06230, Turkey (Türkiye)

RECRUITING

Related Publications (15)

• Pan PJ, Wang JC, Tsai CC, Kuo HC. Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array. J Chin Med Assoc. 2022 Apr 1;85(4):525-531. doi: 10.1097/JCMA.0000000000000693.

  PMID: 35019866 BACKGROUND

• Salsabil JR, Pane RV, Hasan H, Al Hajiri AZZ. Hypertonic Dextrose Prolotherapy Injection in Grade IV Knee Osteoarthritis with Obesity: A Case Report. Acta Med Indones. 2024 Jul;56(3):349-355.

  PMID: 39463100 BACKGROUND

• Huang K, Cai H. Hypertonic dextrose prolotherapy in osteoarthritis: mechanisms, efficacy, and future research directions. Front Endocrinol (Lausanne). 2025 Aug 4;16:1602727. doi: 10.3389/fendo.2025.1602727. eCollection 2025.

  PMID: 40831953 BACKGROUND

• Arias-Vazquez PI, Tovilla-Zarate CA, Legorreta-Ramirez BG, Burad Fonz W, Magana-Ricardez D, Gonzalez-Castro TB, Juarez-Rojop IE, Lopez-Narvaez ML. Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials. Adv Rheumatol. 2019 Aug 19;59(1):39. doi: 10.1186/s42358-019-0083-7.

  PMID: 31426856 BACKGROUND

• Chen YW, Lin YN, Chen HC, Liou TH, Liao CD, Huang SW. Effectiveness, Compliance, and Safety of Dextrose Prolotherapy for Knee Osteoarthritis: A Meta-Analysis and Metaregression of Randomized Controlled Trials. Clin Rehabil. 2022 Jun;36(6):740-752. doi: 10.1177/02692155221086213. Epub 2022 Mar 8.

  PMID: 35257594 BACKGROUND

• Bae G, Kim S, Lee S, Lee WY, Lim Y. Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis. Anesth Pain Med (Seoul). 2021 Jan;16(1):81-95. doi: 10.17085/apm.20078. Epub 2020 Dec 16.

  PMID: 33348947 BACKGROUND

• Hung CY, Hsiao MY, Chang KV, Han DS, Wang TG. Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res. 2016 Oct 18;9:847-857. doi: 10.2147/JPR.S118669. eCollection 2016.

  PMID: 27799816 BACKGROUND

• Jahangiri A, Moghaddam FR, Najafi S. Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: a double-blind randomized clinical trial. J Orthop Sci. 2014 Sep;19(5):737-43. doi: 10.1007/s00776-014-0587-2. Epub 2014 Aug 27.

  PMID: 25158896 BACKGROUND

• Sit RWS, Wu RWK, Reeves KD, Rabago D, Chan DCC, Yip BHK, Chung VCH, Wong SYS. Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial. BMC Complement Altern Med. 2018 May 15;18(1):157. doi: 10.1186/s12906-018-2226-5.

  PMID: 29764447 BACKGROUND

• Arden NK, Perry TA, Bannuru RR, Bruyere O, Cooper C, Haugen IK, Hochberg MC, McAlindon TE, Mobasheri A, Reginster JY. Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol. 2021 Jan;17(1):59-66. doi: 10.1038/s41584-020-00523-9. Epub 2020 Oct 28.

  PMID: 33116279 BACKGROUND

• Fu Y, Du Y, Li J, Xi Y, Ji W, Li T. Demonstrating the effectiveness of intra-articular prolotherapy combined with peri-articular perineural injection in knee osteoarthritis: a randomized controlled trial. J Orthop Surg Res. 2024 May 5;19(1):279. doi: 10.1186/s13018-024-04762-4.

  PMID: 38705988 BACKGROUND

• Wu YT, Chen YP, Lam KHS, Reeves KD, Lin JA, Kuo CY. Mechanism of Glucose Water as a Neural Injection: A Perspective on Neuroinflammation. Life (Basel). 2022 Jun 2;12(6):832. doi: 10.3390/life12060832.

  PMID: 35743863 BACKGROUND

• Guzel I, Gul D, Akpancar S, Lyftogt J. Effectiveness of Perineural Injections Combined with Standard Postoperative Total Knee Arthroplasty Protocols in the Management of Chronic Postsurgical Pain After Total Knee Arthroplasty. Med Sci Monit. 2021 Feb 6;27:e928759. doi: 10.12659/MSM.928759.

  PMID: 33547269 BACKGROUND

• Garcia-Triana SA, Toro-Sashida MF, Larios-Gonzalez XV, Fuentes-Orozco C, Mares-Pais R, Barbosa-Camacho FJ, Guzman-Ramirez BG, Pintor-Belmontes KJ, Rodriguez-Navarro D, Brancaccio-Perez IV, Esparza-Estrada I, Bernal-Hernandez A, Gonzalez-Ojeda A. The Benefit of Perineural Injection Treatment with Dextrose for Treatment of Chondromalacia Patella in Participants Receiving Home Physical Therapy: A Pilot Randomized Clinical Trial. J Altern Complement Med. 2021 Jan;27(1):38-44. doi: 10.1089/acm.2020.0287. Epub 2020 Nov 20.

  PMID: 33217236 BACKGROUND

• Ebnerasooli S, Barghi A, Nasseri K, Moghimi N. Peri-articular Dextrose Prolotherapy: Investigating the Effect of Injection Site on Knee Osteoarthritis Pain: A Double-Blind, Randomized, Clinical Trial. Anesth Pain Med. 2024 Mar 27;14(2):e140966. doi: 10.5812/aapm-140966. eCollection 2024 Apr.

  PMID: 39411379 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee; Pain

Interventions

Glucose

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Central Study Contacts

Nadide Koca, M.D.

CONTACT

+905376843434; nadide.koca@gmail.com

Hakan Genç, PROF. M.D.

CONTACT

05359780666; hakangenc06@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, M.D., Physical Medicine and Rehabilitation

Study Record Dates

• First Submitted: January 25, 2026
• First Posted: February 2, 2026
• Study Start: February 2, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)