Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses

NCT07868614 | Recruiting

• 1 other identifier: 24-008786
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device compared with the standard Alpha Omega device with either a tungsten standard-of-care microelectrode (for microelectrode recordings), or a carbon-fiber microelectrode (for neurotransmitter recordings). The number of microelectrodes used for both the tungsten and the carbon-fiber version will be the same as the standard-of-care.

Conditions

Essential Tremor; Parkinson's Disease; Dystonia

Keywords

Deep brain stimulation surgery

Outcome Measures

Primary Outcomes (1)

• Agreement between MAVEN device and Alpha Omega device

  Total number of times the MAVEN device is in agreement with the standard of care Alpha Omega device.

  Baseline

Study Arms (2)

Tungsten fiber microelectrode

Standard of care Tungsten microelectrode and cables will be utilized, and a splitter adaptor cable will route the data to both the standard Alpha Omega device and also to MAVEN, for comparison of MER readings.

Device: Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)

Carbon fiber microelectrode

A carbon fiber microelectrode will be utilized (in lieu of the tungsten microelectrode) and a splitter adaptor cable will route the data to both the standard Alpha Omega device and also to MAVEN, for comparison of MER readings.

Device: Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)

Interventions

Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN) DEVICE

During deep brain stimulation (DBS) surgery, the MAVEN device will be used in parallel with the currently used Alpha Omega Device to compare the quality of electrophysiologic readings.

Carbon fiber microelectrode; Tungsten fiber microelectrode

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Mayo Clinic patients undergoing deep brain stimulation (DBS) surgery with Dr. Kendall Lee.

You may qualify if:

• Mayo Clinic patients already scheduled to undergo DBS surgery with Dr. Kendall Lee fora movement disorder.

You may not qualify if:

• Patients not approved for DBS surgery by the multidisciplinary DBS committee.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55905, United States

RECRUITING

MeSH Terms

Conditions

Essential Tremor; Parkinson Disease; Dystonia

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Synucleinopathies; Neurodegenerative Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Kendall Lee, M.D.

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Neurosurgery Study Team

CONTACT

507-293-7354; lee.kendall@mayo.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 5, 2026
• First Posted: October 9, 2026
• Study Start: July 29, 2025
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: October 9, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)